College football picks today: Week 13 Friday best bets include Florida State vs. North Carolina State play [11/21/2025]

Today’s college football picks for November 21, 2025 are here, with Florida State vs. North Carolina State and Hawaii vs. UNLV among the top plays identified by our model across Friday’s college football play.

Dimers’ predictive analytics engine runs 24/7, going over the latest football odds to unearth real betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of college football picks tonight [11/21, updated 7:35PM ET]

Below, you’ll find today’s top 10 college football bets, ranked by edge for Friday, November 21, 2025.

Florida State vs. North Carolina State over 58.5 points (-115)

• Edge: 6.4%
• Probability: 59.8%
• Matchup: Florida State vs. North Carolina State (8:00PM ET, Friday)

Our model has identified value on over 58.5 points in Florida State vs. North Carolina State at -115 odds. A 59.8% probability produces an edge of 6.4%, making this the strongest play for today's college football slate.

Hawaii vs. UNLV over 64.5 points (-104)

• Edge: 3.1%
• Probability: 54.1%
• Matchup: Hawaii vs. UNLV (10:30PM ET, Friday)

Hawaii vs. UNLV over 64.5 points carries a 3.1% edge and a probability of 54.1% at -104 odds, according to our model.

East Carolina vs. UTSA over 62.5 points (-105)

• Edge: 8.3%
• Probability: 59.6%
• Matchup: East Carolina vs. UTSA (3:30PM ET, Saturday)

An 8.3% edge and 59.6% probability make East Carolina vs. UTSA over 62.5 points at a value play in the East Carolina vs. UTSA matchup, per our model.

Kansas vs. Iowa State over 55.5 points (-105)

• Edge: 8.3%
• Probability: 59.5%
• Matchup: Kansas vs. Iowa State (12:00PM ET, Saturday)

Kansas vs. Iowa State over 55.5 points at -105 odds presents a 8.3% edge, with simulations resulting in a probability of 59.5%.

Sam Houston State ML (+200)

• Edge: 7.8%
• Probability: 41.1%
• Matchup: Sam Houston State vs. Middle Tennessee (3:00PM ET, Saturday)

Our model finds value on Sam Houston State to win at +200 odds, supported by an edge of 7.8%.

Baylor ML (+198)

• Edge: 7.7%
• Probability: 41.2%
• Matchup: Baylor vs. Arizona (1:00PM ET, Saturday) Our model has uncovered value on Baylor ML at +198 odds. A 41.2% probability produces a 7.7% edge, making this a strong play for today's college football action.

Georgetown +4.5 (-113)

• Edge: 7.6%
• Probability: 60.7%
• Matchup: Georgetown vs. Holy Cross (4:00PM ET, Saturday)

A 7.6% edge on a 60.7% probability makes Georgetown +4.5 at -113 odds a solid value play in today's Georgetown vs. Holy Cross matchup.

Fordham +4.5 (-113)

• Edge: 7.6%
• Probability: 60.7%
• Matchup: Fordham vs. Merrimack (12:00PM ET, Saturday)

Our model projects value on Fordham +4.5 at -113 odds. A 60.7% probability produces a 7.6% edge, making Fordham the favorable side in Saturday’s matchup.

Eastern Washington ML (+134)

• Edge: 7.3%
• Probability: 50%
• Matchup: Eastern Washington vs. Cal Poly (5:00PM ET, Saturday)

Rounding out our top 10 bets, Eastern Washington to defeat Cal Poly at +134 odds shows a 50% probability and a 7.3% edge.

NCAAF best bets summary: Friday, 11/21/2025

As of 7:35PM ET, here are our top college football bets by edge recommended by our model:

Matchup	Bet	Odds	Edge	Probability
Florida State vs. North Carolina State	Over 58.5 Points	-115 @ DraftKings	6.4%	59.8%
Hawaii vs. UNLV	Over 64.5 Points	-104 @ FanDuel	3.1%	54.1%
East Carolina vs. UTSA	Over 62.5 Points	-105 @ DraftKings	8.3%	59.6%
Kansas vs. Iowa State	Over 55.5 Points	-105 @ FanDuel	8.3%	59.5%
Sam Houston State vs. Middle Tennessee	Sam Houston State ML	+200 @ BetMGM	7.8%	41.1%
Baylor vs. Arizona	Baylor ML	+198 @ FanDuel	7.7%	41.2%
Georgetown vs. Holy Cross	Georgetown +4.5	-113 @ FanDuel	7.6%	60.7%
Fordham vs. Merrimack	Fordham +4.5	-113 @ FanDuel	7.6%	60.7%
Eastern Washington vs. Cal Poly	Eastern Washington ML	+134 @ FanDuel	7.3%	50%

List of upcoming college football games to bet on now

• Florida State vs. North Carolina State (8:00PM ET, Friday)
• Hawaii vs. UNLV (10:30PM ET, Friday)
• Missouri vs. Oklahoma (12:00PM ET, Saturday)
• Rutgers vs. Ohio State (12:00PM ET, Saturday)
• Miami Florida vs. Virginia Tech (12:00PM ET, Saturday)
• Louisville vs. Southern Methodist (12:00PM ET, Saturday)
• Minnesota vs. Northwestern (12:00PM ET, Saturday)
• Tulsa vs. Army (12:00PM ET, Saturday)
• Kansas vs. Iowa State (12:00PM ET, Saturday)
• Delaware vs. Wake Forest (12:00PM ET, Saturday)

More college football betting

For further insights into this week's NCAAF action, check out the latest from the Dimers Sports Betting Podcast:

Conclusion

Our college football best bets are locked and loaded for November 21, 2025, featuring plays such as over 58.5 points in the Florida State vs. North Carolina State matchup and over 64.5 points in the Hawaii vs. UNLV matchup. Powered by advanced simulations, these picks are here to boost your betting game.

This article, enhanced by AI and automation, aims to deliver accurate college football insights quickly, with human oversight ensuring high editorial quality. Our predictions are based on current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

All odds and probabilities in this article are correct and accurate at the time of publication.

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