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Cavaliers vs. Pistons prediction: Detroit favored to win Friday's NBA matchup [2/27/2026]

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Written by Ryan Leaver

Get Cleveland Cavaliers vs Detroit Pistons predictions for NBA Friday.

Cleveland Cavaliers-Detroit Pistons Predictions and Game Preview.
Cleveland Cavaliers vs. Detroit Pistons NBA prediction for Friday, February 27, 2026.

The Detroit Pistons will take on the Cleveland Cavaliers in NBA action at Little Caesars Arena on Friday, starting at 7:00 PM ET.

Based on the latest simulations and today’s injury updates, Dimers' advanced NBA model predicts the Pistons as the most likely winner of the Cavaliers vs. Pistons game.

This prediction follows the latest NBA Injury Report, which suggests the Pistons lineup will feature stars like Cade Cunningham, Jalen Duren and Tobias Harris, while the Cavaliers will look to Dennis Schroder, Jaylon Tyson and Jarrett Allen.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and player prop picks.

Cavs vs. Pistons prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the result of Friday's NBA matchup between the Cavaliers and Pistons 10,000 times as part of our NBA predictions coverage.

Our leading predictive model currently gives the Pistons a 73% chance of beating the Cavaliers. Our predicted final score has the Pistons winning 117-110.

According to our model, the Cavaliers (+8.5) have a 55% chance of covering the spread, while the over/under total of 227.5 points has an equal 50-50 chance of hitting.

 

Cavaliers vs. Pistons odds

We have sourced the best NBA odds in America for this game, which are listed here:

Bet Type Cavaliers Pistons
Spread +8.5 (-105) -8.5 (-112)
Moneyline +290 -340
Total o227.5 (-110) u227.5 (-110)

All odds are correct at the time of publication and are subject to change.

Cavaliers vs. Pistons picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

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Written by
Ryan Leaver
Senior Sports and Betting Editor

Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.

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