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Bengals vs. Bills prediction: Buffalo favored to win in NFL Week 14, 2025
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Cincinnati Bengals vs Buffalo Bills predictions for NFL Sunday.
NFL Week 14 action continues on Sunday at 1:00PM ET as the Cincinnati Bengals take on the favored Buffalo Bills at Highmark Stadium.
Based on the latest simulation results, Dimers' advanced NFL model projects the Bills as the most likely winner of the Bengals vs. Bills game.
This article offers an expanded analysis of Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.
Bengals vs. Bills prediction: Who will win and cover?
Since our Bengals-Bills predictions earlier in the week, we have simulated the result of Sunday's NFL matchup between the Bengals and Bills 10,000 times as part of our NFL predictions coverage.
Our independent predictive model gives the Bills a 65% chance of defeating the Bengals in Week 14 of the NFL season. Our predicted final score has the Bills winning 29-24.
According to our model, the Bengals (+5.5) have a 54% chance of covering the spread, while the over/under total of 55 points has a 54% chance of staying under.
To see win probabilities for every matchup this week, check out our expert NFL Week 14 straight up picks.
Bengals vs. Bills odds
We have sourced the best NFL odds in America for this game, which are listed here:
| Bet Type | Bengals | Bills |
|---|---|---|
| Spread | +5.5 (+104) | -5.5 (-128) |
| Moneyline | +235 | -285 |
| Total | o55 (-110) | u55 (-110) |
All odds are correct at the time of publication and are subject to change.
Bengals vs. Bills picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Bengals +5.5 | +104 |
| Moneyline | Bengals | +235 |
| Total | Under 55 | -110 |
According to our NFL best bets, the top play to make on this game is Bengals to win.
Bengals vs. Bills TD scorers
Who will score a touchdown in Bengals vs. Bills?
According to our list of touchdown scorer predictions for Week 14, James Cook is most likely to score an anytime touchdown in Bengals vs. Bills.
Our projections give Cook a 57.5% chance of scoring a TD at Highmark Stadium, while the running back is an 11.8% chance of registering the first touchdown the game.
Anytime touchdown scorer predictions
Cincinnati Bengals
| Player | Anytime TD Probability |
|---|---|
| Ja'Marr Chase (WR) | 48.6% |
| Chase Brown (RB) | 41.6% |
| Tee Higgins (WR) | 39.2% |
| Samaje Perine (RB) | 24.2% |
| Andrei Iosivas (WR) | 17.5% |
Buffalo Bills
| Player | Anytime TD Probability |
|---|---|
| James Cook (RB) | 57.5% |
| Josh Allen (QB) | 52.3% |
| Khalil Shakir (WR) | 28.9% |
| Dalton Kincaid (TE) | 28.2% |
| Gabe Davis (WR) | 21.4% |
First touchdown scorer predictions
Cincinnati Bengals
| Player | First TD Probability |
|---|---|
| Ja'Marr Chase (WR) | 9.7% |
| Chase Brown (RB) | 7.9% |
| Tee Higgins (WR) | 7.3% |
| Samaje Perine (RB) | 4.0% |
| Andrei Iosivas (WR) | 2.8% |
Buffalo Bills
| Player | First TD Probability |
|---|---|
| James Cook (RB) | 11.8% |
| Josh Allen (QB) | 10.2% |
| Khalil Shakir (WR) | 4.7% |
| Dalton Kincaid (TE) | 4.6% |
| Gabe Davis (WR) | 3.3% |
Bengals vs Bills player props
Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Bengals and Bills. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 14 games.
Quarterbacks
Of the starting quarterbacks, the Bengals' Joe Burrow is projected for 257 passing yards, while the Bills' Josh Allen is expected to throw for 236 yards.
| Player | Proj. Pass Yards |
|---|---|
| Joe Burrow (CIN) | 257 |
| Josh Allen (BUF) | 236 |
Bengals rushing
| Player | Proj. Rush Yards |
|---|---|
| Chase Brown | 57 |
| Samaje Perine | 36 |
| Joe Burrow | 10 |
Bills rushing
| Player | Proj. Rush Yards |
|---|---|
| James Cook | 103 |
| Josh Allen | 34 |
| Ty Johnson | 13 |
Bengals receiving
| Player | Proj. Rec. Yards |
|---|---|
| Ja'Marr Chase | 88 |
| Tee Higgins | 59 |
| Mike Gesicki | 25 |
| Chase Brown | 23 |
| Andrei Iosivas | 21 |
Bills receiving
| Player | Proj. Rec. Yards |
|---|---|
| Khalil Shakir | 50 |
| Dalton Kincaid | 38 |
| Keon Coleman | 28 |
| Gabe Davis | 28 |
| Dawson Knox | 21 |
Bengals vs. Bills game-day updates and essential details
The NFL Week 14 action between the Bills and Bengals at Highmark Stadium is scheduled to commence at 1:00PM ET.
- Who: Cincinnati Bengals vs. Buffalo Bills
- Date: Sunday, December 7, 2025
- Time: 1:00PM ET/10:00AM PT
- Venue: Highmark Stadium
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Conclusion
We predict the Bills, with a 65% win probability, will likely beat the Bengals in Week 14 of the NFL season.
AI and automation have enhanced this article to quickly deliver accurate Bengals vs. Bills insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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