White Sox vs. Brewers prediction: Why Milwaukee is favored to win MLB Opening Day matchup [3/26/2026]

The Milwaukee Brewers will take on the Chicago White Sox on Opening Day of the 2022 MLB season at American Family Field on Thursday, commencing at 2:10 PM ET.

Jacob Misiorowski (0-0, 0.00 ERA) will get the ball for the Brewers, while the White Sox will counter with Shane Smith (0-0, 0.00 ERA).

Based on updated simulation results, Dimers' precision-tuned MLB model projects the Brewers as the most likely winner of the White Sox vs. Brewers game.

This article offers further insights into Thursday's matchup, including best bets and picks.

White Sox vs. Brewers prediction: Who will win on MLB Opening Day?

Using innovative machine learning and data, we have simulated the outcome of Thursday's MLB game between the White Sox and Brewers, forming part of our MLB predictions coverage.

Our famous predictive model currently gives the Brewers a 62% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 56% chance of covering the run line, while the over/under total of 7.5 runs has a 53% chance of going over.

White Sox vs. Brewers odds [3/26/2026]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

White Sox vs. Brewers picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our MLB best bets, the top play to make on this game is White Sox to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

White Sox vs. Brewers game-day updates and essential details

Thursday's MLB action between the Brewers and White Sox at American Family Field is scheduled to begin at 2:10 PM ET.

• Who: Chicago White Sox vs. Milwaukee Brewers
• Date: Thursday, March 26, 2026
• Time: 2:10 PM ET/11:10AM PT
• Venue: American Family Field

Conclusion

We predict the Brewers, with a 62% win probability, will likely beat the White Sox on Thursday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Brewers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.