White Sox vs. Astros Prediction: Houston Predicted to Win Wednesday's MLB Matchup [6/11/2025]

The Houston Astros will square off with the Chicago White Sox in MLB action at Daikin Park on Wednesday, starting at 8:10PM ET.

Ryan Gusto (3-3, 4.78 ERA) will be on the bump for the Astros, pitting him against Sean Burke (3-6, 4.03 ERA) for the White Sox.

Based on updated simulations, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has simulated the outcome of Wednesday's CHI White Sox-Houston game 10,000 times," said Dimers' Chief Content Officer, Nick Slade.

"With the latest updates and numerous other variables, we estimate the Astros' chance of winning at 64%, with the White Sox at 36%."

For further insights into Wednesday's matchup, including best bets and picks, visit our interactive White Sox vs. Astros predictions page.

Astros vs. White Sox Prediction: Who Will Win, Cover the Run Line?

Using powerful machine learning and data, we have simulated the result of Wednesday's MLB matchup between the White Sox and Astros 10,000 times as part of our MLB predictions coverage.

Our independent predictive model gives the Astros a 64% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the over/under total of 8 runs has a 51% chance of staying under.

White Sox vs. Astros Odds [6/11/2025]

We have researched the best MLB odds in America for this game, which are listed here:

Bet Type	White Sox	Astros
Run Line	+1.5 (-145)	-1.5 (+125)
Moneyline	+148	-172
Total	o8 (-118)	u8 (+100)

All odds are correct at the time of publication and are subject to change.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.

White Sox vs. Astros Picks and Best Bets

Our model's biggest edge in today's White Sox vs. Astros matchup is on the run line.

Our expert predictions, aligned with the latest odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full set of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Video

Calling Our Shot produces daily MLB betting content, including the latest best bets featured below.

White Sox vs. Astros Game-Day Updates and Essential Details

Wednesday's MLB matchup between the Astros and White Sox at Daikin Park is scheduled to start at 8:10PM ET.

• Who: Chicago White Sox vs. Houston Astros
• Date: Wednesday, June 11, 2025
• Time: 8:10PM ET/5:10PM PT
• Venue: Daikin Park

Dimers.com's comprehensive preview of Wednesday's White Sox vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any CHI White Sox vs. Houston picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

Key MLB Betting Guides and Insights

• Explore how MLB odds work and dive into MLB live betting strategies
• Understand where sports odds come from and how they're applied to baseball matchups
• Learn how to use Dimers Futures to find long-term betting opportunities as the World Series draws closer
• Stay informed with where online sports betting is currently legal and which betting sites are safest to use
• Boost your success with strategies to win at sports betting and explore why MLB is one of the best leagues to bet on

Conclusion

We predict the Astros, with a 64% win probability, will likely beat the White Sox on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate White Sox vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on MLB

Stay up-to-date with the latest MLB betting news and MLB parlay picks throughout the season. Plus, our World Series odds offer the latest probabilities for the World Series, American League, National League and each division.