White Sox vs. Diamondbacks prediction: Why Arizona is favored to win Tuesday's MLB matchup [4/21/2026]

MLB action continues on Tuesday at 9:40 PM ET as the Chicago White Sox square off with the Arizona Diamondbacks at Chase Field.

Merrill Kelly (1-0, 3.38 ERA) will be the starting pitcher for the Diamondbacks, while the White Sox are going with Sean Burke (0-2, 4.43 ERA).

Based on the latest simulation results, Dimers' advanced MLB model predicts the Diamondbacks as the most likely winner of the White Sox vs. Diamondbacks game.

This article offers an expanded analysis of Tuesday's matchup, including best bets and picks.

White Sox vs. Diamondbacks prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Tuesday's MLB game between the White Sox and Diamondbacks, forming part of our MLB predictions coverage.

Our leading predictive model gives the Diamondbacks a 59% chance of beating the White Sox.

According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the over/under total of nine runs has a 56% chance of going over.

White Sox vs. Diamondbacks odds [4/21/2026]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

White Sox vs. Diamondbacks picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: