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Read Article White Sox vs. Diamondbacks prediction: Why Arizona is favored to win Tuesday's MLB matchup [4/21/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Chicago White Sox vs Arizona Diamondbacks predictions for MLB Tuesday.
MLB action continues on Tuesday at 9:40 PM ET as the Chicago White Sox square off with the Arizona Diamondbacks at Chase Field.
Merrill Kelly (1-0, 3.38 ERA) will be the starting pitcher for the Diamondbacks, while the White Sox are going with Sean Burke (0-2, 4.43 ERA).
Based on the latest simulation results, Dimers' advanced MLB model predicts the Diamondbacks as the most likely winner of the White Sox vs. Diamondbacks game.
This article offers an expanded analysis of Tuesday's matchup, including best bets and picks.
White Sox vs. Diamondbacks prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Tuesday's MLB game between the White Sox and Diamondbacks, forming part of our MLB predictions coverage.
Our leading predictive model gives the Diamondbacks a 59% chance of beating the White Sox.
According to our model, the White Sox (+1.5) have a 57% chance of covering the run line, while the over/under total of nine runs has a 56% chance of going over.
White Sox vs. Diamondbacks odds [4/21/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | White Sox | Diamondbacks |
|---|---|---|
| Run Line | +1.5 (-155) | -1.5 (+135) |
| Moneyline | +130 | -144 |
| Total | o9 (-105) | u9 (+100) |
All odds are correct at the time of publication and are subject to change.
White Sox vs. Diamondbacks picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Diamondbacks -1.5 | +135 |
| Moneyline | Diamondbacks | -144 |
| Total | Over 9 | -105 |
According to our MLB best bets, the top play to make on this game is Over 9 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
White Sox vs. Diamondbacks game-day updates and essential details
Tuesday's MLB matchup between the Diamondbacks and White Sox at Chase Field is scheduled to start at 9:40 PM ET.
- Who: Chicago White Sox vs. Arizona Diamondbacks
- Date: Tuesday, April 21, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Chase Field
Conclusion
We predict the Diamondbacks, with a 59% win probability, will likely beat the White Sox in Tuesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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