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Cubs vs. Dodgers prediction: Dodgers favored to win Saturday's MLB matchup [4/25/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Chicago Cubs vs Los Angeles Dodgers predictions for MLB Saturday.
The Los Angeles Dodgers and Chicago Cubs will lock horns in MLB action at UNIQLO Field at Dodger Stadium on Saturday, starting at 7:15 PM ET.
Roki Sasaki (0-2, 6.11 ERA) will be the starting pitcher for the Dodgers, pitting him against Colin Rea (3-0, 3.00 ERA) for the Cubs.
Based on the latest simulation results, Dimers' proven MLB model gives the Dodgers a slight edge with a 54% win probability over the Cubs.
This article offers a closer look at Saturday's Cubs vs. Dodgers matchup, including best bets and picks.
Cubs vs. Dodgers prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of Saturday's MLB game between the Cubs and Dodgers, forming part of our MLB predictions coverage.
Our leading predictive model gives the Dodgers a 54% chance of defeating the Cubs.
According to our model, the Cubs (+1.5) have a 62% chance of covering the run line, while the over/under **total of 9.5 runs **.
Cubs vs. Dodgers odds [4/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cubs | Dodgers |
|---|---|---|
| Run Line | +1.5 (-180) | -1.5 (+155) |
| Moneyline | +109 | -125 |
| Total | o9.5 (+100) | u9.5 (-102) |
All odds are correct at the time of publication and are subject to change.
Cubs vs. Dodgers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Dodgers -1.5 | +155 |
| Moneyline | Dodgers | -125 |
| Total | Under 9.5 | -102 |
According to our MLB best bets, the top play to make on this game is Under 9.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cubs vs. Dodgers game-day updates and essential details
Saturday's MLB game between the Dodgers and Cubs at UNIQLO Field at Dodger Stadium is scheduled to begin at 7:15 PM ET.
- Who: Chicago Cubs vs. Los Angeles Dodgers
- Date: Saturday, April 25, 2026
- Time: 7:15 PM ET/4:15PM PT
- Venue: UNIQLO Field at Dodger Stadium
Conclusion
We predict the Dodgers, with a 54% win probability, will likely beat the Cubs in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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