Cubs vs. Astros Prediction: Houston Predicted to Win Saturday's MLB Matchup [6/28/2025]

The Houston Astros will square off with the Chicago Cubs in MLB action at Daikin Park on Saturday, starting at 7:15PM ET.

The Astros will have Lance McCullers (1-2, 4.91 ERA) as their starting pitcher, while the Cubs will counter with Colin Rea (4-3, 4.42 ERA).

Based on updated simulation results, Dimers' proven MLB model (see Dimers Pro for full access) predicts the Astros as the most likely winner of today's game.

"Our team has used the latest data to run 10,000 simulations of Saturday's Cubs-Astros game," said Dimers' Chief Content Officer, Nick Slade.

"By incorporating recent updates and various other inputs, we estimate that the Astros are more likely to win, while the Cubs have a lower chance of victory."

For expanded analysis of Saturday's matchup, including best bets and picks, visit our interactive Cubs vs. Astros predictions page.

Astros vs. Cubs Prediction: Who Will Win?

Using innovative machine learning and data analysis, we have simulated the result of Saturday's MLB game between the Cubs and Astros 10,000 times as part of our MLB predictions coverage.

Our leading predictive model gives the Astros a 54% chance of defeating the Cubs.

According to our model, the 8.5-run over/under has a 51% chance of staying under.

Cubs vs. Astros Odds [6/28/2025]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type	Cubs	Astros
Moneyline	-102	-112
Total	o8.5 (-102)	u8.5 (-115)

All odds are correct at the time of publication and are subject to change.

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Cubs vs. Astros Picks and Best Bets

Our model's strongest edge in today's Cubs vs. Astros matchup is on the moneyline.

Our expert predictions, aligned with the best odds, reveal the best MLB picks and MLB best bets for every game throughout the season.

Unlimited access to our full suite of picks, including this one, is available via Dimers Pro.

Calling Our Shot's Best Bets Today

Calling Our Shot produces daily MLB betting content, including the best bets featured below.

Cubs vs. Astros Game-Day Updates and Essential Details

Saturday's MLB matchup between the Astros and Cubs at Daikin Park is scheduled to start at 7:15PM ET.

• Who: Chicago Cubs vs. Houston Astros
• Date: Saturday, June 28, 2025
• Time: 7:15PM ET/4:15PM PT
• Venue: Daikin Park

Dimers.com's full preview of Saturday's Cubs vs. Astros matchup includes our prediction, picks and the latest betting odds.

Before making any Cubs vs. Astros picks, be sure to check out the latest MLB predictions and betting advice from Dimers Pro.

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Conclusion

We predict the Astros, with a 54% win probability, will likely beat the Cubs on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Cubs vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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