Blackhawks vs. Sabres prediction: Buffalo favored to win Friday's NHL matchup [11/21/2025]

The Buffalo Sabres and Chicago Blackhawks will lock horns in the NHL at KeyBank Center on Friday, starting at 7:00PM ET.

Based on updated simulations, Dimers' proven NHL model predicts the Sabres as the most likely winner of the Blackhawks vs. Sabres game.

This article offers further insights into Friday's matchup, including projected goal scorers, best bets and player prop picks.

Hawks vs. Sabres prediction: Who will win and cover?

As part of Dimers' NHL predictions coverage—and following a review of recent results—our pregame model has generated moneyline, puck line, and over/under probabilities for Friday's clash between the Blackhawks and Sabres.

Our independent predictive model gives the Sabres a 58% chance of beating the Blackhawks.

According to our model, the Blackhawks (+1.5) have a 63% chance of covering the puck line, while the 6-goal over/under has a 52% chance of going over.

Blackhawks vs. Sabres odds

We have sourced the best NHL odds in America for this game, which are listed here:

Bet Type	Blackhawks	Sabres
Puck Line	+1.5 (-160)	-1.5 (+142)
Moneyline	+155	-175
Total	o6 (-130)	u6 (+100)

All odds are correct at the time of publication and are subject to change.

Blackhawks vs. Sabres picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Puck Line	Blackhawks +1.5	-160
Moneyline	Blackhawks	+155
Total	Under 6	+100

According to our best NHL bets, the top play to make on this game is Blackhawks to win.

Blackhawks vs. Sabres player props

Who will score a goal in Blackhawks vs. Sabres?

According to our model, Tage Thompson is most likely to score an anytime goal in Blackhawks vs. Sabres.

Our projections give Thompson a 44.7% chance of scoring a goal at KeyBank Center, while the star is a 9.1% chance of registering the first goal the game.

Anytime goal scorer predictions

Chicago Blackhawks

Player	Anytime Goal Probability
Connor Bedard	38.6%
Tyler Bertuzzi	31.1%
Frank Nazar	30.2%
Ilya Mikheyev	29.4%
Ryan Donato	26.4%

Buffalo Sabres

Player	Anytime Goal Probability
Tage Thompson	44.7%
Alex Tuch	32.9%
Jason Zucker	24.6%
Jack Quinn	23.8%
Ryan McLeod	23.1%

First goal scorer predictions

Chicago Blackhawks

Player	First Goal Probability
Connor Bedard	7.2%
Frank Nazar	5.7%
Tyler Bertuzzi	5.2%
Ilya Mikheyev	5.2%
Ryan Donato	4.5%

Buffalo Sabres

Player	First Goal Probability
Tage Thompson	9.1%
Alex Tuch	6.0%
Jason Zucker	4.5%
Ryan McLeod	4.3%
Jack Quinn	3.9%

Hawks vs. Sabres game-day updates and essential details

Friday's game between the Sabres and Blackhawks at KeyBank Center is scheduled to begin at 7:00PM ET.

• Who: Chicago Blackhawks vs. Buffalo Sabres
• Date: Friday, November 21, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: KeyBank Center

Conclusion

We predict the Sabres, with a 58% win probability, will likely beat the Blackhawks on Friday.

AI and automation have enhanced this article to quickly deliver accurate Blackhawks vs. Sabres insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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