Charlotte vs. South Florida prediction: South Florida favored to win in college football Week 6, 2025

South Florida will face Charlotte in Week 6 college football action at Raymond James Stadium on Friday, with kickoff at 7:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects the South Florida as the most likely winner of today's game.

For further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Charlotte vs. South Florida predictions page.

Charlotte vs. South Florida prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the result of Charlotte vs. South Florida 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives South Florida a 96% chance of defeating Charlotte. Our predicted final score has South Florida winning 41-13.

According to our model, the bookies have got it right, and Charlotte and South Florida each have a 50% chance of covering the spread, while the 55.5-point over/under also has an equal 50-50 chance of hitting.

Charlotte vs. South Florida odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Charlotte	South Florida
Spread	+28.5 (-110)	-28.5 (-102)
Moneyline	+2200	-6502
Total	o55.5 (-102)	u55.5 (-125)

All odds are correct at the time of publication and are subject to change.

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Charlotte vs. South Florida picks and best bets

Our model's biggest edge in today's Charlotte vs. South Florida matchup is on the spread.

Our expert predictions, aligned with the current odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Charlotte vs. South Florida game-day updates and essential details

Friday's college football game between South Florida and Charlotte at Raymond James Stadium is scheduled to begin at 7:00PM ET.

• Who: Charlotte vs. South Florida
• Date: Friday, October 3, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Raymond James Stadium

Dimers' full preview of Friday's Charlotte vs. South Florida matchup includes our prediction, picks and the latest betting odds.

Before making any Charlotte vs. South Florida picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

Conclusion

We predict South Florida, with a 96% win probability, will likely beat Charlotte on Friday.

AI and automation have enhanced this article to quickly deliver accurate Charlotte vs. South Florida insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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