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Charleston vs. Duke prediction: Duke favored to win women's March Madness First Round matchup [3/20/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get Charleston vs Duke predictions for college basketball Friday.
Women's college basketball action continues on Friday at 11:30 AM ET as Charleston locks horns with Duke at Cameron Indoor Stadium.
Based on updated simulation results, Dimers' new women's basketball model projects Duke as the most likely winner of the Charleston vs. Duke game.
This article offers an expanded analysis of Friday's matchup, including best bets and picks.
Charleston vs. Duke prediction: Who will win and advance to the Second Round?
Using innovative machine learning and data, we have simulated the result of Friday's NCAAW Tournament game between Charleston and Duke 10,000 times as part of our women's college basketball predictions coverage.
Our leading predictive model gives Duke a 99% chance of beating Charleston.
According to our model, the 131.5-point over/under has a 52% chance of going over.
Charleston vs. Duke odds
We have sourced the best women's college basketball odds in America for this game, which are listed here:
| Bet Type | Charleston | Duke |
|---|---|---|
| Spread | +33.5 (-110) | -33.5 (-110) |
| Total | o131.5 (-110) | u131.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Charleston vs. Duke picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Charleston +33.5 | -110 |
| Total | Over 131.5 | -110 |
According to our women's college basketball best bets, the top play to make on this game is over 131.5 points.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Charleston vs. Duke game-day updates and essential details
Friday's women's basketball matchup between Duke and Charleston at Cameron Indoor Stadium is scheduled to start at 11:30 AM ET.
- Who: Charleston vs. Duke
- Date: Friday, March 20, 2026
- Time: 11:30 AM ET/8:30AM PT
- Venue: Cameron Indoor Stadium
- March Madness stage: First Round
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Conclusion
We predict Duke, with a 99% win probability, will likely beat Charleston this women's March Madness First Round matchup.
AI and automation have enhanced this article to quickly deliver accurate Charleston vs. Duke insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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