CBB Parlay Picks for second-round March Madness games today, Saturday, March 21

The second round of the 2026 CBB Tournament begins on Saturday, March 21, and Dimers has teamed up with bet365 Sportsbook to bring you data-backed boosted CBB bets every single round of the tournament, from today's CBB parlay all the way through the National Championship in Indianapolis on April 6.

With bracket chaos around every corner, the tournament offers some of the best college basketball parlay opportunities of the entire sports calendar and we're looking to take advantage with some Dimers model insights today.

Dimers runs thousands of simulations for every CBB matchup, providing users with win probabilities, spread projections, and total predictions for each game, so you're never flying blind, especially with the new Dimers App where you can unlock a free three-day trial of Dimers Pro today, giving you every single value bet across the opening days of the tournament!

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How to find Dimers CBB bets in the Dimers App

Each day of the tournament, Dimers will identify the best betting value in each CBB tournament game, with our college basketball predictions covering the following markets:

• Moneyline predictions for every tournament game
• Against the spread (ATS) picks backed by simulation data
• Point total (over/under) projections
• Player props (points, rebounds, assists, and more)

Dimers Pros have complete access to daily predictions on the Dimers website and in the Dimers App, so don't miss out on your three-day free trial to give you insights across the tournament's opening rounds.

CBB Parlay Picks Today - Saturday, March 21

We've selected these picks using a combination of Dimers CBB best bets and game predictions to find a combination of value and probability that gives us the best chance to win our CBB parlay.

Today's parlay targets a pair of favorites that our model gives at least a 60% probability to win to each of them, boosting their odds to do so with bet365.

CBB Parlay Bet: Vanderbilt ML

Game: Vanderbilt vs. Nebraska

Time: 8:45 PM ET

Dimers gives Vanderbilt a 60% shot to advance, and the numbers back it up.

Sophomore guard Tyler Tanner leads the Commodores with 19.1 points and 5.1 assists per game, and was the best player on the floor in the first round, dropping 26 points in the win over McNeese State. Forward Tyler Nickel rounds out a deep scoring group with 13.5 points per game while leading the team with 102 made three-pointers. 

Offensively, Vanderbilt has a significant edge and faces a Huskers defense that surrenders just 65.6 points per game, just outside the Top 20 rankings nationally, but Vanderbilt's offensive firepower and tournament momentum give them the edge alongside the Dimers model prediction.

CBB Parlay Bet: Michigan State ML

Game: Michigan State vs. Louisville

Time: 2:45 PM ET

Michigan State is the right side to be on, and Louisville's injury situation makes this even cleaner.

Louisville's projected NBA draft pick Mikel Brown Jr. has been ruled out through at least the second round, a massive blow given he averaged 18.2 points per game this season.

Without him, Louisville looked sloppy in their first-round win over South Florida, committing a season-high 22 turnovers and sneaking by with a four-point win.

Meanwhile, Michigan State looked dominant against their lesser opponent. Carson Cooper posted 20 points and 10 rebounds, while Jeremy Fears Jr. dished out 11 assists in their 92-67 blowout of North Dakota State.

The Spartans rank third nationally in rebounding margin and should impose their size advantage on a Cardinals team already playing short-handed

Boosted CBB Parlay Odds

Thanks to bet365 sportsbook, we get boosted odds on this CBB parlay, to raise it from odds of +157 to +199 for an even bigger payout.

Grab this boost at bet365 and good luck if tailing along today and for the rest of the tournament!

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