Buffalo Bills vs. Houston Texans: Experts release early Week 12 predictions [2025]

The Buffalo Bills and Houston Texans will meet in Week 12 of the NFL season at NRG Stadium on Thursday, November 20, 2025, starting at 8:15PM ET.

Early simulations from Dimers' trusted NFL model favor the Bills as the most likely winner of this AFC matchup.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Bills vs. Texans predictions page.

Buffalo vs. Houston early predictions

Leveraging trusted machine learning and analysis, we have simulated the Bills vs. Texans game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Bills 69%, Texans 31%
• Predicted final score: Bills 24-19 Texans
• Spread: Bills (-5.5) 46%, Texans (+5.5) 54%
• Total points (43.5): Over 50%, Under 50%

As of November 17, 2025, these Bills-Texans calculations and predictions reflect the latest data and insights available.

Bills vs. Texans Week 12 details

The NFL Week 12 matchup between the Texans and Bills at NRG Stadium is scheduled for November 20, 2025.

• Who: Buffalo Bills vs. Houston Texans
• Date: Thursday, November 20, 2025
• Time: 8:15PM ET/5:15PM PT
• Venue: NRG Stadium

Bills vs. Texans opening odds

We've researched the best betting odds across America for this Week 12 game, which are listed here:

• Spread: Bills -5.5 (-108), Texans +5.5 (-105)
• Moneyline: Bills -250, Texans +225
• Total: Over/Under 43.5 (-102/-110)

Odds may continue to move—track live changes via our NFL odds page.

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Conclusion

We predict the Bills, with a 69% win probability, will likely beat the Texans in Week 12 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Bills vs. Texans game, with human oversight maintaining high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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