Bills vs. Panthers prediction: Why Buffalo is favored to win in NFL Week 8, 2025

NFL Week 8 action continues on Sunday at 1:00PM ET as the Buffalo Bills lock horns with the Carolina Panthers at Bank of America Stadium.

Based on updated simulations, Dimers' proven NFL model predicts the Bills as the most likely winner of the Bills vs. Panthers game.

This article offers a closer look at Sunday's matchup, including touchdown scorer projections, best bets and player prop picks.

Bills vs. Panthers prediction: Who will win, cover the spread?

Since our Bills-Panthers predictions earlier in the week, we have simulated the outcome of Sunday's NFL game between the Bills and Panthers 10,000 times as part of our NFL predictions coverage.

Our independent predictive model currently gives the Bills a 73% chance of defeating the Panthers in Week 8 of the NFL season. Our predicted final score has the Bills winning 26-20.

According to our model, the Panthers (+7) have a 54% chance of covering the spread, while the over/under total of 48.5 points has a 53% chance of staying under.

To see win probabilities for every matchup this week, check out our expert NFL Week 8 straight up picks.

Bills vs. Panthers odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Bills	Panthers
Spread	-7 (-120)	+7 (+100)
Moneyline	-395	+315
Total	o48.5 (-105)	u48.5 (-115)

All odds are correct at the time of publication and are subject to change.

Bills vs. Panthers picks and best bet

Our predictions, matched with the listed odds, reveal the top betting picks for this game, detailed in Dimers' NFL best bets, crafted from expert modeling and analysis:

Bet Type	Pick	Bet Now
Spread	Panthers +7	+100
Moneyline	Panthers	+315
Total	Under 48.5	-115

According to our NFL best bets, the top play to make on this game is Panthers +7 at the spread.

Bills vs. Panthers TD scorers

Who will score a touchdown in Bills vs. Panthers?

According to our list of touchdown scorer predictions for today, James Cook is most likely to score an anytime touchdown in Bills vs. Panthers.

Our projections give Cook a 56.7% chance of getting in for six at Bank of America Stadium, while the running back is a 13.0% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Buffalo Bills

Player	Anytime TD Probability
James Cook (RB)	56.7%
Josh Allen (QB)	45.0%
Keon Coleman (WR)	28.2%
Dalton Kincaid (TE)	27.9%
Khalil Shakir (WR)	27.3%

Carolina Panthers

Player	Anytime TD Probability
Rico Dowdle (RB)	33.4%
Tetairoa McMillan (WR)	32.3%
Chuba Hubbard (RB)	30.6%
Xavier Legette (WR)	20.9%
Jalen Coker (WR)	12.8%

First touchdown scorer predictions

Buffalo Bills

Player	First TD Probability
James Cook (RB)	13.0%
Josh Allen (QB)	9.3%
Keon Coleman (WR)	5.1%
Dalton Kincaid (TE)	5.1%
Khalil Shakir (WR)	5.0%

Carolina Panthers

Player	First TD Probability
Rico Dowdle (RB)	7.6%
Tetairoa McMillan (WR)	7.3%
Chuba Hubbard (RB)	6.8%
Xavier Legette (WR)	4.4%
Jalen Coker (WR)	2.5%

Bills vs Panthers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Bills and Panthers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 8 games.

Quarterbacks

Of the starting quarterbacks, the Bills' Josh Allen is projected for 238 passing yards, while the Panthers' Andy Dalton is expected to throw for 222 yards.

Player	Proj. Pass Yards
Josh Allen (BUF)	238
Andy Dalton (CAR)	222

Bills rushing

Player	Proj. Rush Yards
James Cook	76
Josh Allen	34
Ray Davis	19

Panthers rushing

Player	Proj. Rush Yards
Rico Dowdle	56
Chuba Hubbard	44
Andy Dalton	7

Bills receiving

Player	Proj. Rec. Yards
Khalil Shakir	53
Keon Coleman	46
Dalton Kincaid	43
Tyrell Shavers	22
James Cook	18

Panthers receiving

Player	Proj. Rec. Yards
Tetairoa McMillan	62
Xavier Legette	39
Jalen Coker	30
Ja'Tavion Sanders	21
Tommy Tremble	16

Bills vs. Panthers game-day updates and essential details

The NFL Week 8 matchup between the Panthers and Bills at Bank of America Stadium is scheduled to begin at 1:00PM ET.

• Who: Buffalo Bills vs. Carolina Panthers
• Date: Sunday, October 26, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Bank of America Stadium

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Conclusion

We predict the Bills, with a 73% win probability, will likely beat the Panthers in Week 8 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Bills vs. Panthers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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