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Red Sox vs. Astros prediction: Boston favored to win Wednesday's MLB matchup [4/1/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Boston Red Sox vs Houston Astros predictions for MLB Wednesday.
The Houston Astros will face the Boston Red Sox in MLB action at Daikin Park on Wednesday, starting at 2:10 PM ET.
The Astros will send Mike Burrows (0-1, 7.94 ERA) to the mound, while the Red Sox will counter with Garrett Crochet (1-0, 0.00 ERA).
Based on the latest simulations, Dimers' advanced MLB model predicts the Red Sox as the most likely winner of the Red Sox vs. Astros game.
This article offers an expanded analysis of Wednesday's matchup, including best bets and picks.
Red Sox vs. Astros prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the result of Wednesday's MLB matchup between the Red Sox and Astros, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Red Sox a 56% chance of defeating the Astros.
According to our model, the Astros (+1.5) have a 57% chance of covering the run line, while the over/under total of seven runs has a 58% chance of going over.
Red Sox vs. Astros odds [4/1/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Red Sox | Astros |
|---|---|---|
| Run Line | -1.5 (+129) | +1.5 (-150) |
| Moneyline | -140 | +122 |
| Total | o7 (-112) | u7 (-102) |
All odds are correct at the time of publication and are subject to change.
Red Sox vs. Astros picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Red Sox -1.5 | +129 |
| Moneyline | Astros | +122 |
| Total | Over 7 | -112 |
According to our MLB best bets, the top play to make on this game is Over 7 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Red Sox vs. Astros game-day updates and essential details
Wednesday's MLB game between the Astros and Red Sox at Daikin Park is scheduled to commence at 2:10 PM ET.
- Who: Boston Red Sox vs. Houston Astros
- Date: Wednesday, April 1, 2026
- Time: 2:10 PM ET/11:10AM PT
- Venue: Daikin Park
Conclusion
We predict the Red Sox, with a 56% win probability, will likely beat the Astros on Wednesday.
AI and automation have enhanced this article to quickly deliver accurate Red Sox vs. Astros insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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