Cardinals vs. Buccaneers prediction: Why Tampa Bay is favored to win in NFL Week 13, 2025

The Tampa Bay Buccaneers will square off with the Arizona Cardinals in NFL Week 13 action at Raymond James Stadium on Sunday, commencing at 1:00PM ET.

Based on the latest simulation results, Dimers' advanced NFL model predicts the Buccaneers as the most likely winner of the Cardinals vs. Buccaneers game.

This article offers a closer look at Sunday's matchup, including projected touchdown scorers, best bets and player prop picks.

Cardinals vs. Bucs prediction: Who will win and cover?

Since our Cardinals-Buccaneers predictions earlier in the week, we have simulated the result of Sunday's NFL game between the Cardinals and Buccaneers 10,000 times as part of our NFL predictions coverage.

Our independent predictive model gives the Buccaneers a 66% chance of defeating the Cardinals in Week 13 of the NFL season. Our predicted final score has the Buccaneers winning 24-20.

According to our model, the Buccaneers (-4) have a 51% chance of covering the spread, while the 44.5-point over/under has an equal 50-50 chance of hitting.

To see win probabilities for every matchup this week, check out our expert NFL Week 13 straight up picks.

Cardinals vs. Buccaneers odds

We have sourced the best NFL odds in America for this game, which are listed here:

Bet Type	Cardinals	Buccaneers
Spread	+4 (-110)	-4 (-110)
Moneyline	+185	-210
Total	o44.5 (-110)	u44.5 (-108)

All odds are correct at the time of publication and are subject to change.

Cardinals vs. Buccaneers picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Buccaneers -4	-110
Moneyline	Cardinals	+185
Total	Under 44.5	-108

According to our NFL best bets, the top play to make on this game is Cardinals to win.

Cardinals vs. Buccaneers TD scorers

Who will score a touchdown in Cardinals vs. Buccaneers?

According to our list of touchdown scorer predictions for Week 13, Bam Knight is most likely to score an anytime TD in Cardinals vs. Buccaneers.

Our projections give Knight a 56.9% chance of getting in for six at Raymond James Stadium, while the running back is a 12.8% chance of scoring the first touchdown the game.

Anytime touchdown scorer predictions

Arizona Cardinals

Player	Anytime TD Probability
Bam Knight (RB)	56.9%
Trey McBride (TE)	38.1%
Marvin Harrison (WR)	33.6%
Greg Dortch (WR)	25.4%
Michael Wilson (WR)	25.0%

Tampa Bay Buccaneers

Player	Anytime TD Probability
Emeka Egbuka (WR)	41.0%
Bucky Irving (RB)	36.1%
Sean Tucker (RB)	32.8%
Tez Johnson (WR)	30.4%
Cade Otton (TE)	24.1%

First touchdown scorer predictions

Arizona Cardinals

Player	First TD Probability
Bam Knight (RB)	12.8%
Trey McBride (TE)	7.3%
Marvin Harrison (WR)	6.2%
Greg Dortch (WR)	4.4%
Michael Wilson (WR)	4.4%

Tampa Bay Buccaneers

Player	First TD Probability
Emeka Egbuka (WR)	9.9%
Bucky Irving (RB)	8.4%
Sean Tucker (RB)	7.5%
Tez Johnson (WR)	6.8%
Cade Otton (TE)	5.2%

Cardinals vs Buccaneers player props

Discover our predictions for the players likely to lead in passing, rushing and receiving yards for both the Cardinals and Buccaneers. Head to our NFL player projections page now to access a full list of player prop projections for every offensive player in this matchup and all other Week 13 games.

Quarterbacks

Of the starting quarterbacks, the Cardinals' Jacoby Brissett is projected to have a big game with 263 passing yards. The Buccaneers' Baker Mayfield is expected to throw for 235 yards.

Player	Proj. Pass Yards
Jacoby Brissett (ARI)	263
Baker Mayfield (TB)	235

Cardinals rushing

Player	Proj. Rush Yards
Bam Knight	38
Michael Carter	24
Jacoby Brissett	15

Buccaneers rushing

Player	Proj. Rush Yards
Bucky Irving	48
Sean Tucker	35
Rachaad White	20

Cardinals receiving

Player	Proj. Rec. Yards
Trey McBride	69
Michael Wilson	58
Marvin Harrison	55
Greg Dortch	24
Michael Carter	17

Buccaneers receiving

Player	Proj. Rec. Yards
Emeka Egbuka	66
Cade Otton	40
Chris Godwin	36
Tez Johnson	33
Sterling Shepard	19

Cardinals vs. Bucs game-day updates and essential details

The NFL Week 13 matchup between the Buccaneers and Cardinals at Raymond James Stadium is scheduled to start at 1:00PM ET.

• Who: Arizona Cardinals vs. Tampa Bay Buccaneers
• Date: Sunday, November 30, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Raymond James Stadium

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Conclusion

We predict the Buccaneers, with a 66% win probability, will likely beat the Cardinals in Week 13 of the NFL season.

AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Buccaneers insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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