Alabama vs. Louisville prediction: Louisville favored to win women's March Madness Second Round matchup [3/23/2026]

Louisville will take on Alabama in March Madness Second Round action at KFC Yum! Center on Monday, beginning at 12:00 PM ET.

Based on the latest simulation results, Dimers' new women's basketball model predicts Louisville as the most likely winner of the Alabama vs. Louisville game.

This article offers an expanded analysis of Monday's matchup, including best bets and picks.

Alabama vs. Louisville prediction: Who will win and advance to the Sweet Sixteen?

Using trusted machine learning and data, we have simulated the result of Monday's NCAAW Tournament game between Alabama and Louisville 10,000 times as part of our women's college basketball predictions coverage.

Our leading predictive model currently gives Louisville a 76% chance of defeating Alabama.

According to our model, the over/under total of 133.5 points has a 51% chance of going over.

Alabama vs. Louisville odds

We have researched the best women's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Alabama vs. Louisville picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our best women's college basketball bets, the top play to make on this game is Alabama to win.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

Alabama vs. Louisville game-day updates and essential details

Monday's women's basketball matchup between Louisville and Alabama at KFC Yum! Center is scheduled to begin at 12:00 PM ET.

• Who: Alabama vs. Louisville
• Date: Monday, March 23, 2026
• Time: 12:00 PM ET/9:00AM PT
• Venue: KFC Yum! Center
• March Madness stage: Second Round

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Conclusion

We predict Louisville, with a 76% win probability, will likely beat Alabama this women's March Madness Second Round matchup.

AI and automation have enhanced this article to quickly deliver accurate Alabama vs. Louisville insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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