Guardians vs. Astros Prediction, Picks and Odds

Our detailed prediction and analysis for the Guardians vs. Astros MLB game on June 21, 2026 is featured below. Drawing from 10,000 game simulations, we provide expert picks, betting odds, and insights.
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Guardians
Slade Cecconi 3-5, 4.60 ERA
1
2
Jun 21, 2:10 PM ET Daikin Park
Astros
Kai-Wei Teng 3-6, 4.31 ERA
Jun 21, 2:10 PM ET Daikin Park
1 2 3 4 5 6 7 8 9 RHE
Guardians
0 0 0 0 1 0 0 0 0 1 4 0
Astros
1 0 0 1 0 0 0 0 X 2 7 0
Live Probabilities
Win %
  • Guardians
    0%
  • Astros
    100%
Win Probability
Baseball infield diamond diagram
Last At Bat
Outs
David Fry strikes out swinging.
Quick Box Score
Guardians Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 T. Bazzana DH4011002.2500.500
2 K. Manzardo 1B4010000.2500.500
3 B. Rocchio SS4010000.2500.500
4 G. Arias 3B4000002.0000.000
5 D. Schneemann 2B4000001.0000.000
6 D. Fry LF2000002.0000.000
7 S. Fairchild RF0000010.0001.000
8 A. Hedges C0000000.0000.000
9 P. Halpin CF3110001.3331.333
Astros Hitting
No.PlayerPosABRHRBIHRBBSOAVGOPS
1 J. Peña SS4010001.2500.750
2 B. Matthews LF0000000.0000.000
3 C. Walker 1B4010001.2500.500
4 I. Paredes 3B4031000.7501.500
5 J. Altuve DH4000001.0000.000
6 J. Meyers CF0000000.0000.000
7 C. Smith RF3000000.0000.000
8 R. Delgado 2B3010000.3330.666
9 C. Vázquez C2000000.0000.000

Guardians vs. Astros: Detailed Breakdown

Matchup Overview

  • Teams: Guardians vs. Astros
  • Date: Sunday, June 21, 2026
  • Time: 2:10 PM ET
  • Venue: Daikin Park

Current Betting Odds

  • Spread: Astros favored at -1.5
  • Total (Over/Under): 8.5
  • Moneyline Odds: Guardians +125, Astros -125

Dimers' Win Probabilities

  • Guardians: 41%
  • Astros: 59%

Dimers' predictive model, renowned for its accuracy, assesses each team's chances by simulating the outcome of the game 10,000 times. This method provides a precise and unbiased view.

Our Prediction: Who Wins?

After extensive simulations, our model gives the Guardians a win probability of 41%, while the Astros have a win probability of 59%. Discover the best spread, over/under, and moneyline odds for the game on this page.

Summary

According to our analysis, the Astros are more likely to beat the Guardians in the MLB game at Daikin Park on Sunday. Discover the best spread, over/under and moneyline odds, picks and probabilities for the game on this page.

Our Guardians vs. Astros predictions, based on sophisticated simulations and current data, guide you in making informed decisions. Remember to bet responsibly and within your financial limits.

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For further insights, explore our expert MLB predictions and the best MLB bets today, while our in-depth analysis includes MLB props, MLB futures, MLB odds, and the latest MLB news.