Sep 2, 2026
Giants vs. Pirates prediction: Why Pittsburgh is favored to win Wednesday's MLB matchup [9/2/2026]
Read Article Blue Jays vs. Guardians prediction: Why Toronto is favored to win Wednesday's MLB matchup [9/2/2026]
Updated: | First published:
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Written by Jason Bevilacqua, Head of Content and Communities
Dimers' simulation model projects a 55.7% win probability for the Blue Jays at Progressive Field.
MLB action continues on Wednesday at 6:40 PM ET as the Toronto Blue Jays lock horns with the Cleveland Guardians at Progressive Field.
Joey Cantillo (9-7, 3.70 ERA) will get the ball for the Guardians, up against Dylan Cease (9-5, 2.34 ERA) for the Blue Jays.
Dimers' advanced MLB model projects the Blue Jays as the most likely winner in this Blue Jays vs. Guardians prediction.
This article offers a closer look at Wednesday's matchup, including best bets and picks.
For more, dive into Dylan Cease's projected pitching stats.
Blue Jays vs. Guardians prediction and odds
Using trusted machine learning and data, we have simulated the outcome of Wednesday's MLB game between the Blue Jays and Guardians, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Blue Jays a 55.7% chance of beating the Guardians.
According to our model, the Guardians (+1.5) have a 57.9% chance of covering the run line, while the 7-run over/under has a 59.7% chance of going over.
Latest betting odds
We have sourced the best MLB odds in America for this game, which are listed here:
- Run Line: Blue Jays -1.5 (+144) / Guardians +1.5 (-153)
- Moneyline: Blue Jays -120, Guardians +117
All odds are correct at the time of publication and are subject to change.
Model picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets in this matchup. Plus, find our best bet for the game below:
- Run line: Blue Jays -1.5 @ +144 via DraftKings
- Moneyline: Blue Jays @ -120 via Novig
- Total: Over 7 @ -115 via Bet365
According to our MLB best bets, the top play to make on this game is Over 7 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Game info & first pitch details
Wednesday's MLB matchup between the Guardians and Blue Jays at Progressive Field is scheduled to commence at 6:40 PM ET.
- Who: Toronto Blue Jays vs. Cleveland Guardians
- Date: Wednesday, September 2, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: Progressive Field
Conclusion
We predict the Blue Jays, with a 55.7% win probability, will likely beat the Guardians in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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