Week 2 opens with one of the highest totals on the board: the Detroit Lions travel to Highmark Stadium to face the Buffalo Bills on Thursday, September 17. Both offenses arrive with the market expecting points, and the
First TD Scorer
market is where the biggest payouts live.
Detroit's backfield remains one of the league's most productive scoring units, and the touchdown market has priced it accordingly. Jahmyr Gibbs opens as the shortest number on the board to find the end zone first — and
has posted an interesting First TD Scorer price around him.
Featured Prop: Jahmyr Gibbs First TD Scorer (+310)
on Jahmyr Gibbs to score the first touchdown of the game against the Bills.
- The board's clear favorite:
Bet365 prices Gibbs' Anytime TD at -240, a roughly 70.6% implied chance and comfortably the shortest anytime number in the game. The book is treating a Gibbs touchdown as close to an expectation rather than a live question, even with Detroit starting as the underdog.
- Predictive Value:
At +310, the First TD market implies roughly a 24.4% chance Gibbs opens the scoring. That is short by First TD standards, and it reflects genuine concentration of red-zone work rather than a speculative longshot — Detroit's scoring hierarchy runs through him.
- Game script:
A 4.5-point spread and a 53.5-point total — among the highest of the week — point to a game with plenty of touchdowns on offer. Detroit trailing by a score for stretches does not shut Gibbs down either, given how much of his work comes through the passing game.
- The competition:
James Cook at +450 leads the Buffalo side of the board, with Josh Allen next at +525 — a reflection of how much short-yardage work the Bills run through their quarterback. Amon-Ra St. Brown sits at +700, DJ Moore at +1000 and Dalton Kincaid at +1200.
Note:
Odds in this article are correct at time of publication and subject to change.
Player Props: Lions Vs. Bills
First & Anytime TD Scorer Odds (Bet365)
| Player |
First TD Odds |
Anytime TD Odds |
| Jahmyr Gibbs |
+310 |
-240 |
| James Cook |
+450 |
-155 |
| Josh Allen |
+525 |
-130 |
| Amon-Ra St. Brown |
+700 |
+110 |
| DJ Moore |
+1000 |
+160 |
| Dalton Kincaid |
+1200 |
+180 |
Lions Vs. Bills Betting Preview
Explore the interactive widget below to discover the latest spread, over/under, and moneyline betting odds and probabilities for the Lions-Bills game at Highmark Stadium.
Check out all the important details on the game, as well as the best odds sourced from the top sportsbooks in the country.
Game Details
The key information you need before the Lions vs. Bills NFL game.
- Teams:
vs.
- Date:
Thursday, September 17, 2026
- Kickoff:
8:15 p.m. EDT
- Location:
Highmark Stadium, Orchard Park, New York
- TV:
Amazon Prime Video
- NFL standings:
- NFL injuries:
Odds (Bet365)
Odds for the key markets in the Lions-Bills matchup.
- Spread:
Lions +4.5 (-110), Bills -4.5 (-110)
- Moneyline:
Lions +185, Bills -225
- Total:
Over/Under 53.5 (-115/-105)
The odds and lines presented here are the best available from selected sports betting sites at the time of publication and are subject to change.
| Sportsbook |
New-user offer |
| Bet365 |
(no bonus code required) |
Bet365 Bet Boosts
Bet365 has posted several boosted Same Game Parlays for the Thursday night opener:
- Bills Mafia (+450, boosted from +400):
Bills Money Line 3-Way + Josh Allen 300+ Passing Yards + Josh Allen 2+ Passing TDs. A $10 stake returns $55.
- Leading the Lions (+800, boosted from +675):
Lions Money Line 3-Way + Jared Goff 275+ Passing Yards + Jared Goff 2+ Passing TDs. A $10 stake returns $90.
- One Man Show (+550, boosted from +500):
Josh Allen 250+ Passing Yards + Josh Allen 40+ Rushing Yards + Josh Allen to Score a TD. A $10 stake returns $65.
- Stuff the Stat Sheet (+550, boosted from +460):
Jahmyr Gibbs to Score 2+ TDs + Jahmyr Gibbs 100+ Rushing Yards + Jahmyr Gibbs 30+ Receiving Yards. A $10 stake returns $65.
Expert Prediction: Lions Vs. Bills
Utilizing state-of-the-art data analysis and advanced algorithms, the experts at
Dimers
have performed 10,000 simulations of the Lions vs. Bills matchup.
According to Dimers' predictive analytics model, the
Bills are more likely to win
at Highmark Stadium. This prediction is based on the model giving the Bills a
68% chance
of winning the game, with a projected final score of
Bills 30, Lions 25.
The model also leans to the
Bills covering the 4.5-point spread, with the projected five-point margin clearing the number. On the total, the model's projected 55-point combined score sits above Bet365's posted 53.5.
These predictions and probabilities are accurate at the time of publication but are subject to potential changes.
Lions Vs. Bills Best Bet
Our top pick for the Lions vs. Bills game is to bet on the
Bills -4.5 (-110)
at Bet365.
Dimers' model projects a five-point Buffalo win, which clears the number, and laying -110 on the spread is materially cheaper than the -225 the moneyline demands for the same read on the game. This expert betting advice is based on world-class modeling and valuable betting intelligence, designed to help you make more informed decisions.
Final Thoughts: Lions Vs. Bills
Thursday night delivers two of the league's most explosive offenses. Buffalo hosts Detroit as a 4.5-point favorite with the moneyline at -225, and Bet365's 53.5-point total is among the highest posted all week, signalling a book that expects both sides to score freely at Highmark Stadium.
The headline angle is Jahmyr Gibbs in the touchdown market. At +310 to strike first, he is the shortest First TD price on the board — and if you'd rather back him without needing the opening score, Bet365's
-240
anytime price is the more conservative route to the same read on Detroit's red-zone hierarchy.
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