Experts Release Chiefs vs. Giants Betting Insights as Xavier Worthy Ruled Out

The Kansas City Chiefs head into Sunday Night Football at MetLife Stadium still searching for their first win of 2025 — and once again, they’ll be without wide receiver Xavier Worthy. According to The Athletic’s Dianna Russini, Worthy is not expected to play against the New York Giants as he continues to recover from a shoulder injury sustained in Week 1. The 2024 first-round pick, who finished second on the team in receiving last season with 59 catches for 638 yards and six touchdowns, has now missed back-to-back games.

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Without Worthy, Kansas City’s passing attack is stretched thin. Rashee Rice remains suspended until Week 7, leaving Marquise “Hollywood” Brown as Patrick Mahomes’ top target. Brown has led the Chiefs in targets, receptions, and yards through two weeks, with Kelce following close behind despite also missing time early. Other contributors, including Tyquan Thornton, JuJu Smith-Schuster, Noah Gray, and Isiah Pacheco, will need to step up if Kansas City hopes to avoid its first 0-3 start since 2014.

The Giants, meanwhile, will look to capitalize on the Chiefs’ shorthanded offense and extend Kansas City’s early-season woes. Led by Russell Wilson and rookie receiver Malik Nabers, New York has shown flashes of balance with Cam Skattebo in the backfield. Our simulations still favor the Chiefs with a 67% chance to win, but the Giants are projected to cover the +5.5 spread more often than not, setting the stage for a primetime battle that could be closer than the odds suggest.

Chiefs Vs. Giants Latest Odds

We've sourced the best betting odds in America for Sunday's clash:

• Spread: Chiefs, -5.5 (-120), Giants, +5.5 (-102)
• Moneyline: Chiefs, -295, Giants, +245
• Total: Over/Under 45 (-110/-110)

New Chiefs Vs. Giants NFL Predictions for Sunday

Leveraging trusted machine learning and analysis, we re-simulated the Chiefs-Giants game 10,000 times as part of our NFL predictions coverage. Here are the updated predictions and insights:

• Straight Up Win Probabilities: Chiefs 67%, Giants 33%
• Predicted Final Score: Chiefs 24-19 Giants
• Spread: Chiefs (-5.5) 46%, Giants (+5.5) 54%
• Total Points (45): Over 48%, Under 52%

As of 9/21/2025, these Chiefs-Giants predictions reflect the latest data and insights available.

Check back in for more NFL prediction alerts as part of our ongoing NFL coverage in September, 2025.

Anytime Touchdown Scorer Predictions

Here are our touchdown probabilities for the Chiefs-Giants matchup:

Kansas City Chiefs

• Travis Kelce: 33.1% probability
• Hollywood Brown: 32.7% probability
• Kareem Hunt: 31.4% probability

New York Giants

• Malik Nabers: 40.1% probability
• Cam Skattebo: 36.2% probability
• Wan'Dale Robinson: 26.7% probability

Chiefs Vs. Giants Projected Box Scores

**Isiah Pacheco is projected to lead rushing for the Chiefs, while **Cam Skattebo is expected to pace the Giants on the ground.

In the receiving game, our projections favor **Hollywood Brown and **Malik Nabers as the likely leaders for their respective teams.

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Chiefs Vs. Giants Key Details

The <a href="https://www.nfl.com/schedules/2024/REG3" target="_blank">NFL Week 3</a> NFL action between the Chiefs and Giants is scheduled for Sunday, September 21, 2025.

• Who: Kansas City Chiefs vs. New York Giants
• Date: Sunday, September 21, 2025
• Approx. Time: 8:20PM ET
• Venue: MetLife Stadium

Further Resources for Betting on Chiefs-Giants

• News: Latest NFL News
• Standings: Updated NFL Standings
• Props: Sunday's NFL Player Prop Picks
• Odds: Best NFL Betting Odds

Conclusion

According to our computer model, the Chiefs, with a 67% win probability, will likely beat the Giants on Sunday.