NFL picks straight up: Week 6, 2026

At Dimers, our Week 6 NFL picks are grounded in data-driven insight, with straight-up picks for all 14 games informed by our latest NFL predictions.

Secure an advantage in your NFL pick 'em contests by following our data-driven NFL Week 6 picks straight up, powered by thousands of game simulations.

Week 6 of the NFL season begins with the Seattle Seahawks facing the Denver Broncos on Thursday night and wraps up with the Washington Commanders taking on the San Francisco 49ers on Monday.

NFL picks this week straight up: Week 6, 2026

Listed below are our Week 6 NFL picks highlighting each team's chances of winning their game this week.

Seattle Seahawks vs. Denver Broncos

The Seahawks kick off Week 6 against the Broncos at Empower Field at Mile High on Thursday night. According to our model, the Seahawks have a 58% chance of winning, while the Broncos have a 42% chance.

For Week 6's opening game, our model highlights NFL player projections, with Jaxon Smith-Njigba (WR) the most likely player from the Seahawks to score the first TD at 13.8%, while J.K. Dobbins (RB) is the top candidate from the Broncos at 7.1%.

Check out our full Seattle Seahawks vs. Denver Broncos prediction ahead of this week's matchup at Empower Field at Mile High, set for Thursday, October 15 at 8:15pm. All times stated in this article are in Eastern Standard Time (EST).

Houston Texans vs. Jacksonville Jaguars

For this week's game between the Texans and the Jaguars, Jacksonville is more likely to win. Our prediction model gives the Jaguars a 61% chance of winning. On the other hand, there is a 39% chance that the Texans will pull off an upset win.

Explore the latest data in this week's Houston Texans vs. Jacksonville Jaguars prediction before kickoff in Jacksonvilleon Sunday at 9:30am.

As the regular season approaches its conclusion, track the top teams with our updated NFL futures, highlighting top Super Bowl contenders.

Tennessee Titans vs. Indianapolis Colts

We are picking the Colts to win their game against the Titans this week, with our powerful NFL model projecting a 74% win probability for the home team. The Titans have a 26% chance of winning.

For betting purposes, the Colts are listed as -7 favorites, with the Titans' moneyline at +280.

Find the complete Tennessee Titans vs. Indianapolis Colts prediction for a closer look at Sunday's 1:00pm game.

Carolina Panthers vs. Philadelphia Eagles

According to our predictive analytics model, the Panthers are the team to beat in this game, with their win probability at 56%. The Eagles, on the other hand, have a 44% chance of winning.

Review the edges and numbers in our Carolina Panthers vs. Philadelphia Eagles prediction for this Sunday 1:00pm clash at Lincoln Financial Field.

Pittsburgh Steelers vs. Tampa Bay Buccaneers

The Steelers have a 61% chance of winning on Sunday afternoon, compared to the Buccaneers' 39% chance of victory. This makes the Pittsburgh Steelers our pick to win at Raymond James Stadium.

See the numbers behind this matchup in the full Pittsburgh Steelers vs. Tampa Bay Buccaneers prediction scheduled for Sunday at 1:00pm at Raymond James Stadium.

Baltimore Ravens vs. Cleveland Browns

The Ravens are favored to win this game, with our model giving them a 70% chance, while the Browns enter the weekend with a 30% chance of causing an upset at Huntington Bank Field.

When it comes to betting on this game, the Ravens' moneyline odds are set at -230, with the home team Browns listed as +5 underdogs.

This week's Baltimore Ravens vs. Cleveland Browns prediction highlights the top values for the game at Huntington Bank Field on Sunday, October 18 at 1:00pm.

New Orleans Saints vs. New York Giants

After 10,000 simulations of Saints vs. Giants this Sunday, our model projects the Saints as the more likely winners with a probability of 55%. Their opponents, the Giants, have a 45% chance of getting the win at home.

Compare projections and odds for this matchup in our New Orleans Saints vs. New York Giants prediction, set for Sunday at 1:00pm.

Chicago Bears vs. Atlanta Falcons

We are picking the Bears, who have a 56% chance of winning the matchup, while the Falcons have a 44% win probability.

Access the full data breakdown in our Chicago Bears vs. Atlanta Falcons prediction ahead of kickoff at Mercedes-Benz Stadium.

New York Jets vs. New England Patriots

The next game of Week 6 sees the Jets take on the Patriots at Gillette Stadium.

We predict the Patriots to win with a probability of 74%, while the Jets are projected to have a win chance of 26%.

As for the Vegas betting odds here, the Patriots are listed as -7 favorites, with the Jets' moneyline odds posted at +275.

Breakdown further probabilities and player projections in the New York Jets vs. New England Patriots prediction for Sunday, October 18 at 1:00pm.

Arizona Cardinals vs. Los Angeles Rams

The likely winner of this matchup is the Rams, who have a projected win chance of 85%, according to DimersBOT. On the other side of this matchup, the Cardinals have a projected win probability of 15%.

Check out our Arizona Cardinals vs. Los Angeles Rams prediction to see where the rest of the numbers lean ahead of Sunday's game in Los Angeles.

Los Angeles Chargers vs. Kansas City Chiefs

We have run our powerful NFL model over this week’s Chargers-Chiefs clash 10,000 times, with the Chiefs coming out as the team to pick. Of those 10,000 simulations, the Chiefs won 7,843 times, with the Chargers winning on 2,157 occasions.

Get direct access to more game projections with our Los Angeles Chargers vs. Kansas City Chiefs prediction before Sunday's clash at Arrowhead Stadium

Buffalo Bills vs. Las Vegas Raiders

Next up is the game between the Bills and Raiders, with our model projecting the road team as the more likely victor, with the Bills rated as having a 71% chance of getting the W. The Raiders, on the other hand, are projected to have a 29% chance of winning.

For those interested in betting on this matchup, the oddsmakers have the Bills' moneyline odds set at -235 for this road game, while the hosting Raiders are listed as +4.5 underdogs.

Examine further probabilities in the full Buffalo Bills vs. Las Vegas Raiders prediction, scheduled for Sunday at 4:25pm.

Dallas Cowboys vs. Green Bay Packers

Our next straight up pick this week is for the Packers to get the win against the Cowboys. After running 10,000 simulations of this matchup, the Green Bay have a win probability of 57%, with the Cowboys at 43%.

View the complete Dallas Cowboys vs. Green Bay Packers prediction for a deeper look at this Sunday's game in Green Bay.

Washington Commanders vs. San Francisco 49ers

With a win probability of 76% on Monday night, our straight up pick for this matchup is the 49ers, while their opponent, the Commanders, have a projected win chance of 24%.

Check out the latest projections in this week's Washington Commanders vs. San Francisco 49ers prediction before kickoff on Monday, October 19 at 8:15pm.

Full list of NFL Week 6 picks straight up

This week's most likely NFL winners, ordered by probability:

• Rams 85.0% vs. Cardinals
• Chiefs 78.4% vs. Chargers
• 49ers 75.9% vs. Commanders
• Colts 74.1% vs. Titans
• Patriots 73.7% vs. Jets
• Bills 71.1% @ Raiders
• Ravens 70.4% @ Browns
• Steelers 61.4% @ Buccaneers
• Jaguars 61.4% vs. Texans
• Seahawks 58.2% @ Broncos
• Packers 56.7% vs. Cowboys
• Panthers 56.2% @ Eagles
• Bears 56.2% @ Falcons
• Saints 54.7% @ Giants

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NFL straight up picks and predictions for Week 6

The NFL Week 6 predictions straight up in this article are accurate at the time of publication but may change.

Dimers.com is the best site for NFL predictions, with our straight up picks trusted by football fans across the country.

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Please note that all NFL odds and probabilities mentioned on this page are subject to change.