Detroit Lions vs. Arizona Cardinals: Experts release early Week 5 preview [2026]

The Detroit Lions and Arizona Cardinals will meet in Week 5 of the NFL season at State Farm Stadium on Sunday, October 11, 2026, starting at 4:25 PM ET.

Early simulations from Dimers' trusted NFL model favor the Lions as the most likely winner of this NFC clash.

For updates all week long, including best bets, player prop projections and touchdown probabilities, check out our interactive Lions vs. Cardinals predictions page.

Detroit vs. Arizona early predictions

Leveraging trusted machine learning and analysis, we have simulated the Lions vs. Cardinals game 10,000 times as part of our NFL predictions coverage. Here are the latest insights:

• Straight up win probabilities: Lions 69.1%, Cardinals 30.9%
• Predicted final score: Lions 29-23 Cardinals
• Spread: Lions (-4.5) 52.7%, Cardinals (+4.5) 47.3%
• Total points (53.5): Over 47.4%, Under 51.3%

As of October 5, 2026, these Lions-Cardinals figures and predictions reflect the latest data and insights available.

Lions vs. Cardinals Week 5 details

Sunday's matchup between the Cardinals and Lions at State Farm Stadium is scheduled for October 11, 2026.

• Who: Detroit Lions vs. Arizona Cardinals
• Date: Sunday, October 11, 2026
• Time: 4:25 PM ET/1:25PM PT
• Venue: State Farm Stadium

Lions vs. Cardinals opening odds

We've researched the best betting odds across America for this Week 5 game, which are listed here:

• Spread: Lions -4.5 (+100), Cardinals +4.5 (-108)
• Moneyline: Lions -203, Cardinals +210
• Total: Over/Under 53.5 (-110/+111)

Odds may continue to move—track live changes via our NFL odds page.

NFL Week 5 promo

Make the most of Dimers' Lions vs. Cardinals predictions by exploring the code "DIMERS" with Polymarket:

Conclusion

We predict the Lions, with a 69.1% win probability, will likely beat the Cardinals in Week 5 of the NFL season. Dimers.com will provide full game coverage closer to kickoff, so stay tuned for updates.

Enhanced by AI and automation, this article delivers quick, accurate insights on the Lions vs. Cardinals matchup, with human oversight maintaining high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee.

More on NFL

Stay informed with the latest NFL betting news and data-led parlay picks all season long. Plus, our Super Bowl odds for top predictions and the best available odds on the Super Bowl, AFC, NFC and each division. &&&&&& AppContent: