Wyoming vs. San Diego State prediction: San Diego State favored to win in college football Week 10, 2025

San Diego State will square off with Wyoming in Week 10 college football action at Snapdragon Stadium on Saturday, starting at 7:00PM ET.

Based on updated simulation results, Dimers' advanced college football model projects the San Diego State as the most likely winner of the Wyoming vs. San Diego State game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Wyoming vs. San Diego State prediction: Who will win, cover the spread?

Using innovative machine learning and data analysis, we have simulated the outcome of Wyoming vs. San Diego State 10,000 times as part of our college football predictions coverage.

Our famous predictive model currently gives San Diego State a 71% chance of defeating Wyoming. Our predicted final score has San Diego State winning 25-18.

According to our model, Wyoming (+10.5) has a 62% chance of covering the spread, while the over/under total of 41.5 points has a 54% chance of staying under.

Wyoming vs. San Diego State odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Wyoming	San Diego State
Spread	+10.5 (-115)	-10.5 (-105)
Moneyline	+325	-400
Total	o41.5 (-110)	u41.5 (-105)

All odds are correct at the time of publication and are subject to change.

Wyoming vs. San Diego State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Wyoming +10.5	-115
Moneyline	Wyoming	+325
Total	Under 41.5	-105

According to our best college football bets, the top play to make on this game is Wyoming +10.5 at the spread.

Wyoming vs. San Diego State game-day updates and essential details

Saturday's college football game between San Diego State and Wyoming at Snapdragon Stadium is scheduled to begin at 7:00PM ET.

• Who: Wyoming vs. San Diego State
• Date: Saturday, November 1, 2025
• Time: 7:00PM ET/4:00PM PT
• Venue: Snapdragon Stadium

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Conclusion

We predict San Diego State, with a 71% win probability, will likely beat Wyoming on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Wyoming vs. San Diego State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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