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Nationals vs. Cubs prediction: Why Cubs are favored to win MLB Opening Day matchup [3/26/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Washington Nationals vs Chicago Cubs predictions for MLB Thursday.
MLB opening day action continues on Thursday at 2:20 PM ET as the Washington Nationals square off with the Chicago Cubs at Wrigley Field.
Matthew Boyd (0-0, 0.00 ERA) will be on the bump for the Cubs, while the Nationals have opted for Cade Cavalli (0-0, 0.00 ERA).
Based on updated simulations, Dimers' refined MLB model projects the Cubs as the most likely winner of the Nationals vs. Cubs game.
This article offers an expanded analysis of Thursday's matchup, including best bets and picks.
Nationals vs. Cubs prediction: Who will win on MLB Opening Day?
Using trusted machine learning and statistical analysis, we have simulated the result of Thursday's MLB game between the Nationals and Cubs, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Cubs a 65% chance of beating the Nationals.
According to our model, the Nationals (+1.5) have a 54% chance of covering the run line, while the over/under total of seven runs has a 52% chance of going over.
Nationals vs. Cubs odds [3/26/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Nationals | Cubs |
|---|---|---|
| Run Line | +1.5 (-130) | -1.5 (+118) |
| Moneyline | +176 | -207 |
| Total | o7 (-105) | u7 (-110) |
All odds are correct at the time of publication and are subject to change.
Nationals vs. Cubs picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cubs -1.5 | +118 |
| Moneyline | Nationals | +176 |
| Total | Over 7 | -105 |
According to our best MLB bets, the top play to make on this game is Over 7 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Nationals vs. Cubs game-day updates and essential details
Thursday's MLB matchup between the Cubs and Nationals at Wrigley Field is scheduled to begin at 2:20 PM ET.
- Who: Washington Nationals vs. Chicago Cubs
- Date: Thursday, March 26, 2026
- Time: 2:20 PM ET/11:20AM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 65% win probability, will likely beat the Nationals on Thursday.
AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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