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Nationals vs. Cubs prediction: Why Cubs are favored to win Saturday's MLB matchup [3/28/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Washington Nationals vs Chicago Cubs predictions for MLB Saturday.
The Chicago Cubs will face the Washington Nationals in MLB action at Wrigley Field on Saturday, starting at 2:20 PM ET.
Cade Horton (0-0, 0.00 ERA) will be the starting pitcher for the Cubs, pitting him against Miles Mikolas (0-0, 0.00 ERA) for the Nationals.
Based on updated simulations, Dimers' upgraded MLB model projects the Cubs as the most likely winner of the Nationals vs. Cubs game.
This article offers an expanded analysis of Saturday's matchup, including best bets and picks.
Nationals vs. Cubs prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the result of Saturday's MLB matchup between the Nationals and Cubs, forming part of our MLB predictions coverage.
Our leading predictive model gives the Cubs a 67% chance of defeating the Nationals.
According to our model, the bookmakers have got it right, and the Nationals and Cubs each have a 50% chance of covering the run line, while the over/under total of 8.5 runs also has an equal 50-50 chance of hitting.
Nationals vs. Cubs odds [3/28/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Nationals | Cubs |
|---|---|---|
| Run Line | +1.5 (+102) | -1.5 (-115) |
| Moneyline | +203 | -245 |
| Total | o8.5 (-118) | u8.5 (+100) |
All odds are correct at the time of publication and are subject to change.
Nationals vs. Cubs picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Nationals +1.5 | +102 |
| Moneyline | Nationals | +203 |
| Total | Under 8.5 | +100 |
According to our MLB best bets, the top play to make on this game is Nationals +1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Nationals vs. Cubs game-day updates and essential details
Saturday's MLB matchup between the Cubs and Nationals at Wrigley Field is scheduled to begin at 2:20 PM ET.
- Who: Washington Nationals vs. Chicago Cubs
- Date: Saturday, March 28, 2026
- Time: 2:20 PM ET/11:20AM PT
- Venue: Wrigley Field
Conclusion
We predict the Cubs, with a 67% win probability, will likely beat the Nationals on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Nationals vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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