Wake Forest vs. Mississippi State prediction: Why Mississippi State is favored to win Duke's Mayo Bowl [2026]

Mississippi State and Wake Forest will meet in the 2026 Duke's Mayo Bowl at Bank of America Stadium on Friday, commencing at 8:00 PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Mississippi State as the most likely winner of the Wake Forest vs. Mississippi State game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Duke's Mayo Bowl prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the outcome of the 2026 Duke's Mayo Bowl 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Mississippi State a 58% chance of beating Wake Forest. Our predicted final score has Mississippi State winning 28-25.

According to our model, Mississippi State (-3) has a 53% chance of covering the spread, while the over/under total of 52.5 points has a 52% chance of staying under.

Duke's Mayo Bowl odds

We have researched the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Wake Forest vs. Mississippi State picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: