UTSA vs. USF prediction: South Florida favored to win in college football Week 11, 2025

South Florida and UTSA will lock horns in Week 11 college football action at Raymond James Stadium on Thursday, starting at 7:30PM ET.

Based on updated simulation results, Dimers' proven college football model projects South Florida as the most likely winner of the UTSA vs. USF game.

This article offers an expanded analysis of Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

UTSA vs. USF prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of UTSA vs. USF 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives South Florida a 78% chance of defeating UTSA. Our predicted final score has South Florida winning 38-24.

According to our model, UTSA (+21.5) has a 61% chance of covering the spread, while the over/under total of 66.5 points has a 57% chance of going over.

UTSA vs. USF odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	UTSA	USF
Spread	+21.5 (-110)	-21.5 (-114)
Moneyline	+1300	-600
Total	o66.5 (-118)	u66.5 (-110)

All odds are correct at the time of publication and are subject to change.

UTSA vs. USF picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	UTSA +21.5	-110
Moneyline	UTSA	+1300
Total	Over 66.5	-118

According to our college football best bets, the top play to make on this game is UTSA to win.

UTSA vs. USF game-day updates and essential details

Thursday's college football action between USF and UTSA at Raymond James Stadium is scheduled to commence at 7:30PM ET.

• Who: UTSA vs. South Florida
• Date: Thursday, November 6, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Raymond James Stadium

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Conclusion

We predict South Florida, with a 78% win probability, will likely beat UTSA on Thursday.

AI and automation have enhanced this article to quickly deliver accurate UTSA vs. South Florida insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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