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UCLA vs. Ohio State prediction: Ohio State favored to win in college football Week 12, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get UCLA vs Ohio State predictions for college football Saturday.
Ohio State will take on UCLA in Week 12 college football action at Ohio Stadium on Saturday, commencing at 7:30PM ET.
Based on updated simulation results, Dimers' advanced college football model predicts Ohio State as the most likely winner of the UCLA vs. Ohio State game.
This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
UCLA vs. Ohio State prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of UCLA vs. Ohio State 10,000 times as part of our college football predictions coverage.
Our leading predictive model gives Ohio State a 99% chance of defeating UCLA. Our predicted final score has Ohio State winning 41-8.
According to our model, the bookmakers have got it right, and UCLA and Ohio State each have a 50% chance of covering the spread, while the over/under total of 46.5 points has a 55% chance of staying under.
UCLA vs. Ohio State odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | UCLA | Ohio State |
|---|---|---|
| Spread | +33.5 (-105) | -33.5 (-106) |
| Moneyline | +5500 | -6502 |
| Total | o46.5 (-110) | u46.5 (-108) |
All odds are correct at the time of publication and are subject to change.
UCLA vs. Ohio State picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | UCLA +33.5 | -105 |
| Moneyline | Ohio State | -6502 |
| Total | Under 46.5 | -108 |
According to our college football best bets, the top play to make on this game is Under 46.5 total points.
For a further guide on betting on this matchup, check out today's odds boost on Buckeyes' QB Julian Sayin.
UCLA vs. Ohio State game-day updates and essential details
Saturday's college football action between Ohio State and UCLA at Ohio Stadium is scheduled to commence at 7:30PM ET.
- Who: UCLA vs. Ohio State
- Date: Saturday, November 15, 2025
- Time: 7:30PM ET/4:30PM PT
- Venue: Ohio Stadium
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Conclusion
We predict Ohio State, with a 99% win probability, will likely beat UCLA on Saturday.
AI and automation have enhanced this article to quickly deliver accurate UCLA vs. Ohio State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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