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Tulane vs. Ole Miss prediction: Why Mississippi is favored to win in college football playoffs first round [2025]
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Tulane vs Ole Miss predictions for college football Saturday.
Mississippi and Tulane will clash in Week 17 college football playoffs action at Vaught-Hemingway Stadium on Saturday, beginning at 3:30 PM ET.
Based on the latest simulation results, Dimers' proven college football model projects Mississippi as the most likely winner of the Tulane vs. Ole Miss game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Tulane vs. Ole Miss prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Tulane vs. Ole Miss 10,000 times as part of our college football predictions coverage.
Our leading predictive model gives Mississippi an 87% chance of defeating Tulane and advancing to play Georgia in the Sugar Bowl Bowl. Our predicted final score has Mississippi winning 35-18.
According to our model, the bookmakers have got it right, and Tulane and Mississippi each have a 50% chance of covering the spread, while the over/under total of 57.5 points has a 58% chance of going over.
Tulane vs. Ole Miss odds
We have sourced the best college football odds in America for this game, which are listed here:
| Bet Type | Tulane | Ole Miss |
|---|---|---|
| Spread | +17.5 (-110) | -17.5 (-106) |
| Moneyline | +625 | -900 |
| Total | o57.5 (-110) | u57.5 (-108) |
All odds are correct at the time of publication and are subject to change.
Tulane vs. Ole Miss picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Mississippi -17.5 | -106 |
| Moneyline | Tulane | +625 |
| Total | Over 57.5 | -110 |
According to our college football best bets, the top play to make on this game is Over 57.5 total points.
Tulane vs. Ole Miss game-day updates and essential details
Saturday's college football game between Ole Miss and Tulane at Vaught-Hemingway Stadium is scheduled to commence at 3:30 PM ET.
- Who: Tulane vs. Mississippi
- Date: Saturday, December 20, 2025
- Time: 3:30 PM ET/12:30PM PT
- Venue: Vaught-Hemingway Stadium
- Playoffs Stage: First Round
The 2025–26 season marks the second year of the expanded 12-team College Football Playoff, which replaced the long-standing four-team system last year..
Under the updated format, the four highest-ranked conference champions earn first-round byes, while seeds 5 through 12 meet in campus-site first-round games on December 20 and 21.
The winner of the Tulane vs. Ole Miss matchup will advance to face Georgia in the Sugar Bowl.
Conclusion
We predict Mississippi, with an 87% win probability, will likely beat Tulane in the first round of the College Football Playoff.
AI and automation have enhanced this article to quickly deliver accurate Tulane vs. Mississippi insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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