Rays vs. White Sox prediction: Why Tampa Bay is favored to win Thursday's MLB matchup [4/16/2026]

MLB action continues on Thursday at 2:10 PM ET as the Tampa Bay Rays take on the Chicago White Sox at Rate Field.

The White Sox will start Jordan Leasure (1-0, 4.00 ERA), pitting him against Steven Matz (3-0, 3.94 ERA) for the Rays.

Based on the latest simulation results, Dimers' advanced MLB model gives the Rays a slight edge with a 52% win probability over the White Sox.

This article offers a closer look at Thursday's Rays vs. White Sox matchup, including best bets and picks.

Rays vs. White Sox prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Thursday's MLB game between the Rays and White Sox, forming part of our MLB predictions coverage.

Our famous predictive model gives the Rays a 52% chance of defeating the White Sox.

According to our model, the White Sox (+1.5) have a 60% chance of covering the run line, while the over/under **total of 8.5 runs **.

Rays vs. White Sox odds [4/16/2026]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Rays vs. White Sox picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: