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Syracuse vs. Notre Dame prediction: Notre Dame favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Syracuse vs Notre Dame predictions for college football Saturday.
Notre Dame will square off with Syracuse in Week 13 college football action at Notre Dame Stadium on Saturday, starting at 3:30PM ET.
Based on the latest simulation results, Dimers' proven college football model predicts Notre Dame as the most likely winner of the Syracuse vs. Notre Dame game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Syracuse vs. Notre Dame prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Syracuse vs. Notre Dame 10,000 times as part of our college football predictions coverage.
Our independent predictive model currently gives Notre Dame a 99% chance of defeating Syracuse. Our predicted final score has Notre Dame winning 42-6.
According to our model, the bookmakers have got it right, and Syracuse and Notre Dame each have a 50% chance of covering the spread, while the over/under total of 51.5 points has a 51% chance of going over.
Syracuse vs. Notre Dame odds
We have researched the best College Football odds in America for this game, which are listed here:
| Bet Type | Syracuse | Notre Dame |
|---|---|---|
| Spread | +36.5 (-108) | -36.5 (-110) |
| Moneyline | +6500 | -50000 |
| Total | o51.5 (-105) | u51.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Syracuse vs. Notre Dame picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Syracuse +36.5 | -108 |
| Moneyline | Notre Dame | -50000 |
| Total | Over 51.5 | -105 |
According to our college football best bets, the top play to make on this game is Over 51.5 total points.
Syracuse vs. Notre Dame game-day updates and essential details
Saturday's college football game between Notre Dame and Syracuse at Notre Dame Stadium is scheduled to start at 3:30PM ET.
- Who: Syracuse vs. Notre Dame
- Date: Saturday, November 22, 2025
- Time: 3:30PM ET/12:30PM PT
- Venue: Notre Dame Stadium
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Conclusion
We predict Notre Dame, with a 99% win probability, will likely beat Syracuse on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Syracuse vs. Notre Dame insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
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