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Read Article Cardinals vs. Pirates prediction: Why Pittsburgh is favored to win Monday's MLB matchup [4/27/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get St. Louis Cardinals vs Pittsburgh Pirates predictions for MLB Monday.
The Pittsburgh Pirates will face the St. Louis Cardinals in MLB action at PNC Park on Monday, beginning at 6:40 PM ET.
The Pirates will start Mason Montgomery (1-0, 3.97 ERA), up against Dustin May (3-2, 5.84 ERA) for the Cardinals.
Based on updated simulations, Dimers' advanced MLB model projects the Pirates as the most likely winner of the Cardinals vs. Pirates game.
This article offers a closer look at Monday's matchup, including best bets and picks.
Cardinals vs. Pirates prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the result of Monday's MLB game between the Cardinals and Pirates, forming part of our MLB predictions coverage.
Our independent predictive model gives the Pirates a 56% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of eight runs has an equal 50-50 chance of hitting.
Cardinals vs. Pirates odds [4/27/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Pirates |
|---|---|---|
| Run Line | +1.5 (-220) | -1.5 (+165) |
| Moneyline | +104 | -118 |
| Total | o8 (-110) | u8 (-104) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Pirates picks and best bet
After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Pirates -1.5 | +165 |
| Moneyline | Pirates | -118 |
| Total | Under 8 | -104 |
According to our MLB best bets, the top play to make on this game is Pirates to win.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Pirates game-day updates and essential details
Monday's MLB matchup between the Pirates and Cardinals at PNC Park is scheduled to begin at 6:40 PM ET.
- Who: St. Louis Cardinals vs. Pittsburgh Pirates
- Date: Monday, April 27, 2026
- Time: 6:40 PM ET/3:40PM PT
- Venue: PNC Park
Conclusion
We predict the Pirates, with a 56% win probability, will likely beat the Cardinals in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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