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Cardinals vs. Tigers prediction: Detroit favored to win Sunday's MLB matchup [4/5/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get St. Louis Cardinals vs Detroit Tigers predictions for MLB Sunday.
The Detroit Tigers will square off with the St. Louis Cardinals in MLB action at Comerica Park on Sunday, starting at 7:20 PM ET.
The Tigers will start Keider Montero (0-0, 0.00 ERA), while the Cardinals have opted for Kyle Leahy (0-1, 7.20 ERA).
Based on updated simulations, Dimers' advanced MLB model predicts the Tigers as the most likely winner of the Cardinals vs. Tigers game.
This article offers further insights into Sunday's matchup, including best bets and picks.
Cardinals vs. Tigers prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Sunday's MLB game between the Cardinals and Tigers, forming part of our MLB predictions coverage.
Our leading predictive model gives the Tigers a 57% chance of defeating the Cardinals.
According to our model, the Cardinals (+1.5) have a 61% chance of covering the run line, while the over/under total of eight runs has an equal 50-50 chance of hitting.
Cardinals vs. Tigers odds [4/5/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Tigers |
|---|---|---|
| Run Line | +1.5 (-180) | -1.5 (+155) |
| Moneyline | +124 | -142 |
| Total | o8 (-110) | u8 (-105) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Tigers picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Tigers -1.5 | +155 |
| Moneyline | Cardinals | +124 |
| Total | Under 8 | -105 |
According to our best MLB bets, the top play to make on this game is Tigers -1.5 at the spread.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. Tigers game-day updates and essential details
Sunday's MLB matchup between the Tigers and Cardinals at Comerica Park is scheduled to begin at 7:20 PM ET.
- Who: St. Louis Cardinals vs. Detroit Tigers
- Date: Sunday, April 5, 2026
- Time: 7:20 PM ET/4:20PM PT
- Venue: Comerica Park
Conclusion
We predict the Tigers, with a 57% win probability, will likely beat the Cardinals on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Cardinals vs. Tigers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice, head to our responsible gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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