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Read Article Cardinals vs. Athletics prediction: Why Athletics is favored to win Wednesday's MLB matchup [5/13/2026]
Updated: | First published:
Written by Ryan Leaver, Senior Sports and Betting Editor
Get St. Louis Cardinals vs Athletics predictions for MLB Wednesday.
The Athletics and St. Louis Cardinals are scheduled to meet in MLB action at Sutter Health Park on Wednesday, starting at 9:40 PM ET.
J.T. Ginn (1-1, 3.62 ERA) will be on the bump for the Athletics, up against Matthew Liberatore (2-1, 4.07 ERA) for the Cardinals.
Based on the latest simulations, Dimers' advanced MLB model projects the Athletics as the most likely winner of the Cardinals vs. Athletics game.
This article offers further insights into Wednesday's matchup, including best bets and picks.
Cardinals vs. A's prediction: Who will win and cover?
Using trusted machine learning and data, we have simulated the result of Wednesday's MLB matchup between the Cardinals and Athletics, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Athletics a 56% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 60% chance of covering the run line, while the 10-run over/under has an equal 50-50 chance of hitting.
Cardinals vs. Athletics odds [5/13/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Cardinals | Athletics |
|---|---|---|
| Run Line | +1.5 (-168) | -1.5 (+140) |
| Moneyline | +119 | -138 |
| Total | o10 (-105) | u10 (-112) |
All odds are correct at the time of publication and are subject to change.
Cardinals vs. Athletics picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Athletics -1.5 | +140 |
| Moneyline | Cardinals | +119 |
| Total | Over 10 | -105 |
According to our MLB best bets, the top play to make on this game is Over 10 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Cardinals vs. A's game-day updates and essential details
Wednesday's MLB matchup between the Athletics and Cardinals at Sutter Health Park is scheduled to commence at 9:40 PM ET.
- Who: St. Louis Cardinals vs. Athletics
- Date: Wednesday, May 13, 2026
- Time: 9:40 PM ET/6:40PM PT
- Venue: Sutter Health Park
Conclusion
We predict the Athletics, with a 56% win probability, will likely beat the Cardinals in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Ryan Leaver uses advanced statistical models and simulations to predict outcomes and provide predictions for the NBA, NFL, college football, college basketball, and soccer. He offers detailed game previews, best bets, props, and futures articles.
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