Southern Miss vs. Arkansas State prediction: Why Southern Miss is favored to win in college football Week 11, 2025

Arkansas State will face the favored Southern Miss in Week 11 college football action at Centennial Bank Stadium on Saturday, commencing at 12:00PM ET.

Based on updated simulations, Dimers' advanced college football model predicts Southern Miss as the most likely winner of the Southern Miss vs. Arkansas State game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Miss vs. Arkansas State prediction: Who will win, cover the spread?

Using trusted machine learning and data analysis, we have simulated the outcome of Southern Miss vs. Arkansas State 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Southern Miss a 66% chance of beating Arkansas State. Our predicted final score has Southern Miss winning 30-23.

According to our model, the bookmakers have got it right, and Southern Miss and Arkansas State each have a 50% chance of covering the spread, while the over/under total of 54.5 points has a 54% chance of going over.

Southern Miss vs. Arkansas State odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	Southern Miss	Arkansas State
Spread	-6.5 (-105)	+6.5 (-110)
Moneyline	-215	+195
Total	o54.5 (-110)	u54.5 (-105)

All odds are correct at the time of publication and are subject to change.

Southern Miss vs. Arkansas State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Southern Miss -6.5	-105
Moneyline	Arkansas State	+195
Total	Over 54.5	-110

According to our college football best bets, the top play to make on this game is Over 54.5 total points.

Southern Miss vs. Arkansas State game-day updates and essential details

Saturday's college football action between Arkansas State and Southern Miss at Centennial Bank Stadium is scheduled to start at 12:00PM ET.

• Who: Southern Miss vs. Arkansas State
• Date: Saturday, November 8, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Centennial Bank Stadium

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Conclusion

We predict Southern Miss, with a 66% win probability, will likely beat Arkansas State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern Miss vs. Arkansas State insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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