...
...
Read Article
Southern California vs. Oregon prediction: Oregon favored to win in college football Week 13, 2025
Updated: | First published:
Written by Mac Douglass, Senior Editor
Get Southern California vs Oregon predictions for college football Saturday.
Oregon will face Southern California in Week 13 college football action at Autzen Stadium on Saturday, starting at 3:30PM ET.
Based on updated simulation results, Dimers' advanced college football model projects Oregon as the most likely winner of the Southern California vs. Oregon game.
This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
Southern California vs. Oregon prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Southern California vs. Oregon 10,000 times as part of our college football predictions coverage.
Our independent predictive model gives Oregon a 74% chance of defeating Southern California. Our predicted final score has Oregon winning 35-24.
According to our model, the bookmakers have got it right, and Southern California and Oregon each have a 50% chance of covering the spread, while the over/under total of 59.5 points also has an equal 50-50 chance of hitting.
Southern California vs. Oregon odds
We have sourced the best College Football odds in America for this game, which are listed here:
| Bet Type | Southern California | Oregon |
|---|---|---|
| Spread | +10.5 (-112) | -10.5 (-106) |
| Moneyline | +320 | -390 |
| Total | o59.5 (-102) | u59.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Southern California vs. Oregon picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Oregon -10.5 | -106 |
| Moneyline | Southern California | +320 |
| Total | Over 59.5 | -102 |
According to our college football best bets, the top play to make on this game is Southern California to win.
Southern California vs. Oregon game-day updates and essential details
Saturday's college football game between Oregon and Southern California at Autzen Stadium is scheduled to begin at 3:30PM ET.
- Who: Southern California vs. Oregon
- Date: Saturday, November 22, 2025
- Time: 3:30PM ET/12:30PM PT
- Venue: Autzen Stadium
Sports betting deal available for Missouri sports fans
To make the most of the upcoming Missouri launch, check out details on the latest Bet365 bonus code "DIMERS" that secures $365 in bonus bets from a $10 bet — win or lose. Don't miss out!
Conclusion
We predict Oregon, with a 74% win probability, will likely beat Southern California on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Southern California vs. Oregon insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.
Mac Douglass specializes in NFL previews for the NFC South and NFC East, MLB best bets, Formula 1 race previews, and professional tennis insights. Combining predictive simulations and data-driven sports analysis, Mac provides in-depth content to elevate the betting experience for sports fans.
Advertiser disclosure