Southern California vs. Notre Dame prediction: Notre Dame favored to win in college football Week 8, 2025

Notre Dame will take on Southern California in Week 8 college football action at Notre Dame Stadium on Saturday, starting at 7:30PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts the Notre Dame as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive Southern California vs. Notre Dame predictions page.

Southern California vs. Notre Dame prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the result of Southern California vs. Notre Dame 10,000 times as part of our college football predictions coverage.

Our famous predictive model gives Notre Dame a 70% chance of defeating Southern California. Our predicted final score has Notre Dame winning 33-24.

According to our model, Southern California (+10.5) has a 55% chance of covering the spread, while the 60.5-point over/under has a 55% chance of going over.

Southern California vs. Notre Dame odds

We have sourced the best college football odds in America for this game, which are listed here:

Bet Type	Southern California	Notre Dame
Spread	+10.5 (-110)	-10.5 (-105)
Moneyline	+310	-370
Total	o60.5 (-105)	u60.5 (-110)

All odds are correct at the time of publication and are subject to change.

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Southern California vs. Notre Dame picks and best bets

Our model's strongest edge in today's Southern California vs. Notre Dame matchup is on the moneyline.

Our expert predictions, matched against the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

Southern California vs. Notre Dame game-day updates and essential details

Saturday's college football action between Notre Dame and Southern California at Notre Dame Stadium is scheduled to begin at 7:30PM ET.

• Who: Southern California vs. Notre Dame
• Date: Saturday, October 18, 2025
• Time: 7:30PM ET/4:30PM PT
• Venue: Notre Dame Stadium

Dimers' full preview of Saturday's Southern California vs. Notre Dame matchup includes our prediction, picks and the latest betting odds.

Before making any Southern California vs. Notre Dame picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict Notre Dame, with a 70% win probability, will likely beat Southern California on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Southern California vs. Notre Dame insights, with human oversight ensuring high editorial quality. Our predictions are drawn from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.