South Dakota vs. Mercer prediction: Why Mercer is favored to win in college football Week 15, 2025

Mercer and South Dakota will lock horns in Week 15 college football action at Five Star Stadium on Saturday, commencing at 12:00PM ET.

Based on updated simulations, Dimers' proven college football model projects Mercer as the most likely winner of the South Dakota vs. Mercer game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

South Dakota vs. Mercer prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of South Dakota vs. Mercer 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives Mercer a 60% chance of defeating South Dakota. Our predicted final score has Mercer winning 30-26.

According to our model, South Dakota (+6) has a 53% chance of covering the spread, while the 54.5-point over/under has a 54% chance of staying under.

South Dakota vs. Mercer odds

We have researched the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

South Dakota vs. Mercer picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: