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Spurs vs. Lakers prediction: Lakers to win, Luka Doncic projected for 34 points in Wednesday's NBA Cup game [12/10/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get San Antonio Spurs vs Los Angeles Lakers predictions for NBA Wednesday.
The Los Angeles Lakers and San Antonio Spurs will meet in NBA Cup quarterfinals action at Crypto.com Arena on Wednesday, with tipoff at 10:00PM ET.
Based on updated simulations and today’s injury news, Dimers' proven NBA model predicts the Lakers as the most likely winner of the Spurs vs. Lakers game.
This prediction follows the latest NBA Injury Report, which suggests the Lakers lineup will feature players like Luka Doncic, Austin Reaves and LeBron James, while the Spurs will rely on De'Aaron Fox, Stephon Castle and Harrison Barnes.
Doncic is expected to deliver a standout performance with a projected 34 points and 4 threes.
This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and player prop picks.
Spurs vs. Lakers prediction: Who will win NBA Cup quarterfinal?
Using trusted machine learning and statistical analysis, we have simulated the result of Wednesday's NBA game between the Spurs and Lakers 10,000 times as part of our NBA predictions coverage.
Our independent predictive model currently gives the Lakers a 71% chance of beating the Spurs. Our predicted final score has the Lakers winning 122-116.
According to our model, the Spurs (+7) have a 53% chance of covering the spread, while the over/under total of 241.5 points has a 53% chance of staying under.
Spurs vs. Lakers odds
We have sourced the best NBA odds in America for this game, which are listed here:
| Bet Type | Spurs | Lakers |
|---|---|---|
| Spread | +7 (-106) | -7 (-114) |
| Moneyline | +225 | -270 |
| Total | o241.5 (-108) | u241.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Spurs vs. Lakers picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Spurs +7 | -106 |
| Moneyline | Spurs | +225 |
| Total | Under 241.5 | -110 |
According to our best NBA bets for Wednesday, the top play to make on this game is Spurs +7 at the spread.
Spurs vs. Lakers player props
Looking for Spurs vs. Lakers NBA prop bets? We use the best information available to project how each team's leading players will perform at Crypto.com Arena.
De'Aaron Fox is expected to lead the Spurs with 22 points, 4 rebounds and 7 assists, while Luka Doncic is projected to have 34 points, 9 rebounds and 9 assists for the Lakers.
Check out our NBA player projections for a full range of projected box scores, including points, assists, rebounds and more, for every game this season.
Spurs prediction
Our model's projected player stats for the Spurs are:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| De'Aaron Fox | 22 | 4 | 7 | 2 | 42 |
| Stephon Castle | 15 | 4 | 6 | 1 | 34 |
| Harrison Barnes | 15 | 4 | 2 | 2 | 26 |
| Devin Vassell | 14 | 4 | 2 | 3 | 27 |
| Dylan Harper | 14 | 4 | 4 | 1 | 28 |
Lakers prediction
Projected points, rebounds, assists and three-pointers made for the Lakers:
| Player | PTS | REB | AST | 3PM | DFS |
|---|---|---|---|---|---|
| Luka Doncic | 34 | 9 | 9 | 4 | 66 |
| Austin Reaves | 25 | 5 | 6 | 3 | 45 |
| LeBron James | 22 | 6 | 7 | 2 | 46 |
| Deandre Ayton | 15 | 9 | 2 | 0 | 33 |
| Rui Hachimura | 13 | 4 | 1 | 2 | 23 |
Spurs vs. Lakers game-day updates and essential details
Wednesday's action between the Lakers and Spurs at Crypto.com Arena is scheduled to start at 10:00PM ET.
- Who: San Antonio Spurs vs. Los Angeles Lakers
- Date: Wednesday, December 10, 2025
- Time: 10:00PM ET/7:00PM PT
- Venue: Crypto.com Arena
- Tournament details: 2025 Emirates NBA Cup
Conclusion
We predict the Lakers, with a 71% win probability, will likely beat the Spurs on Wednesday, with Luka Doncic projected for a game-high 66 fantasy points.
AI and automation have enhanced this article to quickly deliver accurate Spurs vs. Lakers insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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