Phillies vs. Cubs prediction: Why Philadelphia is favored to win Thursday's MLB matchup [4/23/2026]

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Written by Dave Garofolo

Get Philadelphia Phillies vs Chicago Cubs predictions for MLB Thursday.

Philadelphia Phillies-Chicago Cubs Predictions and Game Preview.
Philadelphia Phillies vs. Chicago Cubs MLB prediction for Thursday, April 23, 2026.

The Chicago Cubs will face the Philadelphia Phillies, in what is expected to be a close MLB game, at Wrigley Field on Thursday, beginning at 2:20 PM ET.

Edward Cabrera (2-0, 2.38 ERA) will be the starting pitcher for the Cubs, while the Phillies have opted for Cristopher Sánchez (2-2, 1.59 ERA).

Based on the latest simulations, Dimers' advanced MLB model gives the Phillies a slight edge with a 51% win probability over the Cubs.

This article offers further insights into Thursday's Phillies vs. Cubs matchup, including best bets and picks.

Phillies vs. Cubs prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Thursday's MLB matchup between the Phillies and Cubs, forming part of our MLB predictions coverage.

Our independent predictive model gives the Phillies a 51% chance of beating the Cubs.

According to our model, the Cubs (+1.5) have a 60% chance of covering the run line, while the 9.5-run over/under has a 51% chance of staying under.

 

Phillies vs. Cubs odds [4/23/2026]

We have sourced the best MLB odds in America for this game, which are listed here:

Bet Type Phillies Cubs
Run Line -1.5 (+140) +1.5 (-168)
Moneyline -109 -102
Total o9.5 (-110) u9.5 (-110)

All odds are correct at the time of publication and are subject to change.

Phillies vs. Cubs picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Run Line Phillies -1.5 +140
Moneyline Cubs -102
Total Under 9.5 -110

According to our MLB best bets, the top play to make on this game is Under 9.5 total runs.

These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.

 

Phillies vs. Cubs game-day updates and essential details

Thursday's MLB game between the Cubs and Phillies at Wrigley Field is scheduled to start at 2:20 PM ET.

Conclusion

We predict the Phillies, with a 51% win probability, will likely beat the Cubs in Thursday's MLB matchup.

Additional tools and information for betting safely can be found in our Responsible Gambling hub.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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