Penn State vs. Ohio State prediction: Ohio State favored to win in college football Week 10, 2025

Ohio State and Penn State will lock horns in Week 10 college football action at Ohio Stadium on Saturday, commencing at 12:00PM ET.

Based on the latest simulations, Dimers' advanced college football model predicts the Ohio State as the most likely winner of the Penn State vs. Ohio State game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Penn State vs. Ohio State prediction: Who will win, cover the spread?

Using trusted machine learning and statistical analysis, we have simulated the outcome of Penn State vs. Ohio State 10,000 times as part of our college football predictions coverage.

Our independent predictive model gives Ohio State a 90% chance of defeating Penn State. Our predicted final score has Ohio State winning 32-14.

According to our model, the bookmakers have got it right, and Penn State and Ohio State each have a 50% chance of covering the spread, while the over/under total of 44.5 points has a 55% chance of staying under.

Penn State vs. Ohio State odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	Penn State	Ohio State
Spread	+17.5 (-105)	-17.5 (-105)
Moneyline	+750	-1100
Total	o44.5 (-115)	u44.5 (-102)

All odds are correct at the time of publication and are subject to change.

Penn State vs. Ohio State picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Penn State +17.5	-105
Moneyline	Penn State	+750
Total	Under 44.5	-102

According to our best college football bets, the top play to make on this game is Under 44.5 total points.

Penn State vs. Ohio State game-day updates and essential details

Saturday's college football matchup between Ohio State and Penn State at Ohio Stadium is scheduled to begin at 12:00PM ET.

• Who: Penn State vs. Ohio State
• Date: Saturday, November 1, 2025
• Time: 12:00PM ET/9:00AM PT
• Venue: Ohio Stadium

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Conclusion

We predict Ohio State, with a 90% win probability, will likely beat Penn State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Penn State vs. Ohio State insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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