Penn State vs. Clemson prediction: Why Clemson is favored to win Pinstripe Bowl [2025]

Clemson will face Penn State in the 2025 Pinstripe Bowl at Yankee Stadium on Saturday, commencing at 12:00 PM ET.

Based on the latest simulation results, Dimers' advanced college football model gives Clemson a slight edge with a 52% win probability over Penn State.

This article offers an expanded analysis of Saturday's Penn State vs. Clemson matchup, including an expanded look at the predicted score, best bets and picks.

Pinstripe Bowl prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of the 2025 Pinstripe Bowl 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Clemson a 52% chance of beating Penn State. Our predicted score is Penn State 24-24 Clemson.

According to our model, Penn State (+2.5) has a 54% chance of covering the spread, while the 47.5-point over/under has a 53% chance of staying under.

While there is no way for a college football game to end in a tie, our prediction of 24-24 is based on each team's average score in the above-mentioned simulations of Penn State vs. Clemson.

Pinstripe Bowl odds

We have sourced the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Penn State vs. Clemson picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: