Penn State vs. Clemson prediction: Why Clemson is favored to win Pinstripe Bowl [2025]

Clemson will square off with Penn State in the 2025 Pinstripe Bowl at Yankee Stadium on Saturday, beginning at 12:00 PM ET.

Based on updated simulation results, Dimers' proven college football model gives Clemson a slight edge with a 52% win probability over Penn State.

This article offers a closer look at Saturday's Penn State vs. Clemson matchup, including an expanded look at the predicted score, best bets and picks.

Pinstripe Bowl prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the result of the 2025 Pinstripe Bowl 10,000 times as part of our college football predictions coverage.

Our leading predictive model currently gives Clemson a 52% chance of beating Penn State. Our predicted score is Penn State 24-24 Clemson.

According to our model, Penn State (+2.5) has a 54% chance of covering the spread, while the over/under total of 47.5 points has a 53% chance of staying under.

While there is no way for a college football game to end in a tie, our prediction of 24-24 is based on each team's average score in the above-mentioned simulations of Penn State vs. Clemson.

Pinstripe Bowl odds

We have sourced the best college football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Penn State vs. Clemson picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our college football best bets, the top play to make on this game is Penn State +2.5 at the spread.

Penn State vs. Clemson game-day updates and essential details

Saturday's college football game between Clemson and Penn State at Yankee Stadium is scheduled to commence at 12:00 PM ET.

• Who: Penn State vs. Clemson
• Date: Saturday, December 27, 2025
• Time: 12:00 PM ET/9:00AM PT
• Venue: Yankee Stadium

Conclusion

We predict Clemson, with a 52% win probability, will likely beat Penn State on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Penn State vs. Clemson insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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