Ohio State vs. Purdue prediction: Why Ohio State is favored to win in college football Week 11, 2025

Purdue will square off with the favored Ohio State in Week 11 college football action at Ross-Ade Stadium on Saturday, beginning at 1:00PM ET.

Based on updated simulation results, Dimers' proven college football model predicts Ohio State as the most likely winner of the Ohio State vs. Purdue game.

This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Ohio State vs. Purdue prediction: Who will win, cover the spread?

Using trusted machine learning and data, we have simulated the outcome of Ohio State vs. Purdue 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Ohio State a 97% chance of defeating Purdue. Our predicted final score has Ohio State winning 40-11.

According to our model, Purdue (+30.5) has a 52% chance of covering the spread, while the 49.5-point over/under has a 53% chance of staying under.

Ohio State vs. Purdue odds

We have sourced the best College Football odds in America for this game, which are listed here:

Bet Type	Ohio State	Purdue
Spread	-30.5 (-110)	+30.5 (-110)
Moneyline	-4500	+3000
Total	o49.5 (-110)	u49.5 (-110)

All odds are correct at the time of publication and are subject to change.

Ohio State vs. Purdue picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type	Pick	Bet Now
Spread	Purdue +30.5	-110
Moneyline	Purdue	+3000
Total	Under 49.5	-110

According to our college football best bets, the top play to make on this game is Under 49.5 total points.

Ohio State vs. Purdue game-day updates and essential details

Saturday's college football action between Purdue and Ohio State at Ross-Ade Stadium is scheduled to begin at 1:00PM ET.

• Who: Ohio State vs. Purdue
• Date: Saturday, November 8, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Ross-Ade Stadium

Sports betting deal available for NCAAF Saturday

To make the most of Saturday's massive day of sports, headlined by clashes like this one for college football Saturday, check out details on the latest Bet365 bonus code "DIMERS" that secures $200 in bonus bets from a $5 bet — win or lose. Don't miss out!

Conclusion

We predict Ohio State, with a 97% win probability, will likely beat Purdue on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Ohio State vs. Purdue insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

More on college football

Stay up-to-date with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds offer the most up-to-date probabilities for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.