Northwestern vs. Southern California prediction: Southern California favored to win in college football Week 11, 2025

Southern California will square off with Northwestern in Week 11 college football action at Los Angeles Memorial Coliseum on Friday, starting at 9:00PM ET.

Based on the latest simulations, Dimers' proven college football model predicts Southern California as the most likely winner of the Northwestern vs. Southern California game.

This article offers a closer look at Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Northwestern vs. Southern California prediction: Who will win, cover the spread?

Using powerful machine learning and data, we have simulated the result of Northwestern vs. Southern California 10,000 times as part of our college football predictions coverage.

Our independent predictive model currently gives Southern California an 80% chance of beating Northwestern. Our predicted final score has Southern California winning 31-19.

According to our model, Northwestern (+14.5) has a 54% chance of covering the spread, while the over/under total of 53.5 points has a 60% chance of going over.

Northwestern vs. Southern California odds

We have researched the best College Football odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Northwestern vs. Southern California picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our college football best bets, the top play to make on this game is Over 53.5 total points.

Northwestern vs. Southern California game-day updates and essential details

Friday's college football matchup between Southern California and Northwestern at Los Angeles Memorial Coliseum is scheduled to begin at 9:00PM ET.

• Who: Northwestern vs. Southern California
• Date: Friday, November 7, 2025
• Time: 9:00PM ET/6:00PM PT
• Venue: Los Angeles Memorial Coliseum

Conclusion

We predict Southern California, with an 80% win probability, will likely beat Northwestern on Friday.

AI and automation have enhanced this article to quickly deliver accurate Northwestern vs. Southern California insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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