North Dakota vs. Southern Illinois prediction: North Dakota favored to win in college football Week 8, 2025

Southern Illinois will square off with North Dakota in Week 8 college football action at Saluki Stadium on Saturday, with kickoff at 1:00PM ET.

Based on the latest simulation results, Dimers' advanced college football model projects the North Dakota as the most likely winner of today's game.

For a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks, visit our interactive North Dakota vs. Southern Illinois predictions page.

North Dakota vs. Southern Illinois prediction: Who will win, cover the spread?

Using innovative machine learning and statistical analysis, we have simulated the outcome of North Dakota vs. Southern Illinois 10,000 times as part of our college football predictions coverage.

Our leading predictive model gives North Dakota a 52% chance of defeating Southern Illinois. Our predicted final score has North Dakota winning 29-28.

According to our model, Southern Illinois (+2.5) has a 54% chance of covering the spread, while the over/under total of 59.5 points has a 58% chance of going over.

North Dakota vs. Southern Illinois odds

We have researched the best college football odds in America for this game, which are listed here:

Bet Type	North Dakota	Southern Illinois
Spread	-2.5 (-110)	+2.5 (-110)
Moneyline	-130	+130
Total	o59.5 (-110)	u59.5 (-110)

All odds are correct at the time of publication and are subject to change.

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North Dakota vs. Southern Illinois picks and best bets

Our model's biggest edge in today's North Dakota vs. Southern Illinois matchup is on the spread.

Our expert predictions, aligned with the best odds, reveal the best college football picks and college football best bets for every game throughout the season.

Unlimited access to our complete suite of picks, including this one, is available via Dimers Pro.

North Dakota vs. Southern Illinois game-day updates and essential details

Saturday's college football game between Southern Illinois and North Dakota at Saluki Stadium is scheduled to start at 1:00PM ET.

• Who: North Dakota vs. Southern Illinois
• Date: Saturday, October 18, 2025
• Time: 1:00PM ET/10:00AM PT
• Venue: Saluki Stadium

Dimers' full preview of Saturday's North Dakota vs. Southern Illinois matchup includes our prediction, picks and the latest betting odds.

Before making any North Dakota vs. Southern Illinois picks, be sure to check out the latest college football predictions and betting advice from Dimers Pro.

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Conclusion

We predict North Dakota, with a 52% win probability, will likely beat Southern Illinois on Saturday.

AI and automation have enhanced this article to quickly deliver accurate North Dakota vs. Southern Illinois insights, with human oversight ensuring high editorial quality. Our predictions are sourced from up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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More on college football

Keep up with the latest college football news and CFB parlay picks throughout the season. Plus, our College Football National Championship odds provide the latest projections for the national title game and major conferences.

Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.