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Yankees vs. Astros prediction: Yankees favored to win Saturday's MLB matchup [4/25/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get New York Yankees vs Houston Astros predictions for MLB Saturday.
The Houston Astros will face the New York Yankees in MLB action at Daikin Park on Saturday, beginning at 7:10 PM ET.
The Astros will start Mike Burrows (1-3, 6.75 ERA), while the Yankees are going with Ryan Weathers (1-2, 3.18 ERA).
Based on the latest simulation results, Dimers' advanced MLB model predicts the Yankees as the most likely winner of the Yankees vs. Astros game.
This article offers a closer look at Saturday's matchup, including best bets and picks.
Yankees vs. Astros prediction: Who will win and cover?
Using innovative machine learning and data analysis, we have simulated the result of Saturday's MLB game between the Yankees and Astros, forming part of our MLB predictions coverage.
Our leading predictive model currently gives the Yankees a 55% chance of defeating the Astros.
According to our model, the Astros (+1.5) have a 56% chance of covering the run line, while the 9-run over/under has a 54% chance of going over.
Yankees vs. Astros odds [4/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Yankees | Astros |
|---|---|---|
| Run Line | -1.5 (+110) | +1.5 (-126) |
| Moneyline | -148 | +129 |
| Total | o9 (-102) | u9 (+100) |
All odds are correct at the time of publication and are subject to change.
Yankees vs. Astros picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Astros +1.5 | -126 |
| Moneyline | Astros | +129 |
| Total | Over 9 | -102 |
According to our MLB best bets, the top play to make on this game is Over 9 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Yankees vs. Astros game-day updates and essential details
Saturday's MLB action between the Astros and Yankees at Daikin Park is scheduled to commence at 7:10 PM ET.
- Who: New York Yankees vs. Houston Astros
- Date: Saturday, April 25, 2026
- Time: 7:10 PM ET/4:10PM PT
- Venue: Daikin Park
Conclusion
We predict the Yankees, with a 55% win probability, will likely beat the Astros in Saturday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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