Mets vs. Giants prediction: San Francisco favored to win Saturday's MLB matchup [4/4/2026]

The San Francisco Giants and New York Mets will lock horns in MLB action at Oracle Park on Saturday, starting at 9:05 PM ET.

The Giants will start Landen Roupp (1-0, 0.00 ERA), while the Mets are going with Clay Holmes (1-0, 3.18 ERA).

Based on updated simulations, Dimers' advanced MLB model gives the Giants a slight edge with a 52% win probability over the Mets.

This article offers further insights into Saturday's Mets vs. Giants matchup, including best bets and picks.

Mets vs. Giants prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Saturday's MLB matchup between the Mets and Giants, forming part of our MLB predictions coverage.

Our independent predictive model currently gives the Giants a 52% chance of defeating the Mets.

According to our model, the Giants (+1.5) have a 64% chance of covering the run line, while the over/under total of 7.5 runs has a 56% chance of going over.

Mets vs. Giants odds [4/4/2026]

We have researched the best MLB odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Mets vs. Giants picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: