Home run predictions for Blue Jays vs. Mariners include Cal Raleigh, Julio Rodriguez [10/16/2025]

Our MLB home run predictions for Thursday, October 16, 2025, are here—with Cal Raleigh topping the list based on the latest Dimers Pro simulation data.

Thursday's HR projections pull from our proprietary home run predictions, which highlight the top slugging candidates today.

Home run predictions for October 16, 2025

Player (Team)	HR Projection
Cal Raleigh (Mariners)	23.0%
Eugenio Suarez (Mariners)	19.5%
Julio Rodriguez (Mariners)	17.0%
Anthony Santander (Blue Jays)	🔒
Vladimir Guerrero (Blue Jays)	🔒
Daulton Varsho (Blue Jays)	🔒
Jorge Polanco (Mariners)	🔒
George Springer (Blue Jays)	🔒
Josh Naylor (Mariners)	🔒
Dominic Canzone (Mariners)	🔒

Our analysis shows Raleigh leads today's MLB home run predictions with a 23.0% chance to go yard, followed by Eugenio Suarez (19.5%) and Julio Rodriguez (17.0%).

Anthony Santander and Vladimir Guerrero are among several other sluggers to rank inside the top 10. Want the full list of home run props today—including every player's HR probability for Thursday? Join Dimers Pro now.

Already a Dimers Pro member? Check out today's HR and hitter projections and sort by “To Hit HR” to see every player’s probability of going deep.

Thursday's playoffs home run picks [10/16/2025]

After running 10,000 simulations per matchup and assessing key variables like weather and pitching matchups, Dimers Pro has identified one of the best MLB home run props today.

Anthony Santander (Blue Jays) to hit a home run

• Probability: 17.6%
• Odds: +541
• Edge: 2.0%
• Game: Blue Jays vs. Mariners (8:33PM ET)
• Pitching matchup: Luis Castillo

Ranked as one of the top three most likely players in today's home run predictions, Toronto slugger Anthony Santander offers serious value at +541 with DraftKings Sportsbook, showing an edge of 2.0%—making him one of the strongest home run bets today.

In a matchup against Mariners starter Luis Castillo, Santander shapes up as one of the best home run picks today on Thursday's slate.

For more expert MLB picks and data-backed MLB predictions, join Dimers Pro now. Pro users get full access to a total of Eight home run predictions today, plus hit and RBI projections, pitcher props, and more—perfect for building smarter MLB parlays and round robins.

MLB postseason schedule for today [Thursday, October 16, 2025]

• Blue Jays vs. Mariners (8:33PM ET, Thursday)

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Conclusion

For October 16, 2025, our MLB home run predictions are locked in, with sluggers like Cal Raleigh, Eugenio Suarez and Julio Rodriguez projected to be among the most powerful bats in today’s games. But it's Anthony Santander who stands out as the best value bet, offering a favorable 2.0% edge at +541 odds.

These insights are based on 10,000 game simulations and are designed to help you identify smarter betting opportunities. As always, gamble responsibly. If you or someone you know needs support, call 1-800-GAMBLER.

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