MLB picks today: Tuesday's MLB best bets include Rays vs. Guardians play [4/28/2026]

Today’s MLB picks for April 28, 2026 are here, with Rays vs. Guardians and Mariners vs. Twins among the top plays identified by our model across Tuesday’s MLB action.

Dimers’ predictive analytics engine runs 24/7, scanning the latest baseball odds to uncover legitimate betting edges. The result? Data-backed picks that help Dimers Pro members make smarter decisions.

List of MLB best bets today [4/28, updated 9:31PM ET]

Below, you’ll find today’s best baseball bets, ranked by edge for Tuesday, April 28, 2026.

Rays vs. Guardians over 7 runs (+100)

• Edge: 5.5%
• Probability: 55.5%
• Matchup: Rays vs. Guardians (1:10PM ET, Wednesday)

Our model has identified value on over 7 runs in Rays vs. Guardians at +100 odds. A 55.5% probability produces an edge of 5.5%, making this the strongest play for today's MLB slate.

Mariners vs. Twins over 8 runs (-102)

• Edge: 3.1%
• Probability: 53.6%
• Matchup: Mariners vs. Twins (1:40PM ET, Wednesday)

Mariners vs. Twins over 8 runs carries a 3.1% edge and a probability of 53.6% at -102 odds, according to our model.

Rockies vs. Reds over 9.5 runs (+100)

• Edge: 2.9%
• Probability: 52.9%
• Matchup: Rockies vs. Reds (6:40PM ET, Wednesday)

Rockies vs. Reds over 9.5 runs at +100 odds shows a 2.9% edge, supported by a 52.9% probability in simulations.

Giants vs. Phillies over 7 runs (-105)

• Edge: 2.7%
• Probability: 54%
• Matchup: Giants vs. Phillies (6:40PM ET, Wednesday)

A 2.7% edge and 54% probability make Giants vs. Phillies over 7 runs at a value play in the Giants vs. Phillies matchup, per our model.

Diamondbacks vs. Brewers over 8.5 runs (-110)

• Edge: 2.5%
• Probability: 54.9%
• Matchup: Diamondbacks vs. Brewers (7:40PM ET, Wednesday)

Diamondbacks vs. Brewers over 8.5 runs at -110 odds presents a 2.5% edge, with simulations resulting in a probability of 54.9%.

Astros vs. Orioles over 9 runs (-102)

• Edge: 2.2%
• Probability: 52.7%
• Matchup: Astros vs. Orioles (6:35PM ET, Wednesday)

Our model finds value on over 9 runs in Astros vs. Orioles at -102 odds, supported by an edge of 2.2%.

MLB best bets summary: Tuesday, 4/28/2026

As of 9:31PM ET, here are our top MLB bets by edge recommended by our model:

List of upcoming MLB games to bet on [4/28/2026]

• Cubs vs. Padres (9:40PM ET, Tuesday)
• Royals vs. Athletics (9:40PM ET, Tuesday)
• Marlins vs. Dodgers (10:10PM ET, Tuesday)
• Rays vs. Guardians (1:10PM ET, Wednesday)
• Angels vs. White Sox (1:10PM ET, Wednesday)
• Mariners vs. Twins (1:40PM ET, Wednesday)
• Yankees vs. Rangers (2:35PM ET, Wednesday)
• Marlins vs. Dodgers (3:10PM ET, Wednesday)
• Cubs vs. Padres (4:10PM ET, Wednesday)
• Astros vs. Orioles (6:35PM ET, Wednesday)
• Cardinals vs. Pirates (6:40PM ET, Wednesday)
• Giants vs. Phillies (6:40PM ET, Wednesday)
• Rockies vs. Reds (6:40PM ET, Wednesday)
• Nationals vs. Mets (7:10PM ET, Wednesday)
• Tigers vs. Braves (7:15PM ET, Wednesday)
• D-Backs vs. Brewers (7:40PM ET, Wednesday)

Conclusion

Our MLB best bets are locked and loaded for April 28, 2026, featuring plays such as over 7 runs in the Rays vs. Guardians matchup and over 8 runs in the Mariners vs. Twins matchup. Powered by advanced simulations, these picks are here to boost your betting game.

Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice, head to our Responsible Gambling hub.

All odds and probabilities in this article are correct and accurate at the time of publication.